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Core B - Analytical Core

Extraction, Detection, and Interpretation of PCB Congeners in Complex Matrices

The purpose of the Analytical Core is to support the analytical needs of the isrp investigators. Toward that end, the Analytical Core will provide routine and non-routine analytical service relating to PCB sources, exposures and toxicities. As requested by the project investigators, the Analytical Core will also train personnel and assist in sampling design and implementation.

The Analytical Core(AC) is also deeply engaged in method development. In 2016 the AC developed new methods for extraction of OH-PCBs using acidified solvents, Soxhlet extraction, and Accelerated Solvent Extraction; new methods for passive sampling of PCBs in pore waters using polyethylene; and sample cleanup and concentration using a new Fluid Management System (FMS). New Standard Operating Procedures were prepared and released.

Core Leader: Keri C. Hornbuckle, PhD

  • Dr. Hornbuckle is an environmental scientist and engineer with experience in the analysis of PCBs in environmental samples and laboratory animal tissues. She is a Professor in the Department of Civil and Environmental Engineering. She will be responsible for all aspects of the Analytical Core activities, including handling and extraction of samples and analysis by capillary gas chromatography (GC), liquid chromatography (HPLC), mass spectrometry, and various other analytical methods. Dr. Hornbuckle will oversee the development of automated air sample analysis Standard Operating Methods and methods for more specialized applications. She will consult directly with Project Leaders to refine analysis to maximize sensitivity and selectivity for PCBs and metabolites in various matrices.

Hans-Joachim Lehmler, PhD

  •  Dr. Lehmler is a chemist with experience in the synthesis and analysis of PCBs in animal tissues with a special emphasis on the analysis of chiral PCB congeners. He is currently appointed as Associate Scientist in the UI Department for Occupational and Environmental Health. In addition to being a member of the Analytical Core of the isrp, he will also serve as the Leader of the Synthesis Core. This will facilitate the interaction between the Analytical and Synthesis Core.

Ananya Sen Gupta

  • Dr. Sen Gupta will lead studies concerning complex instrumental signals produced through the analysis of hundreds of air samples collected by the ISRP Projects. She is an Assistant Professor at the University of Iowa who has collected and analyzed for PCBs and related compounds since 2006.

 Kai Wang, PhD

  • Dr. Wang is a Professor in Biostatistics at the University of Iowa. His research interests include the  application and development of statistical technologies related to biomedical studies including bioinformatics, statistical genetics, and nonparametric estimation under biased sampling.




Program and Research Support Cores

The Program and Research Support Cores communicate with all projects, thus fostering regular communication and interaction among all components (projects and cores) of the isrp.

Program Support Cores