Select Publications and Datasets by Topic Area

Hua, J.; Marek, RF; Hornbuckle, KC, Polyurethane foam emission samplers to identify sources of airborne polychlorinated biphenyls (PCBs) from glass block windows and other room surfaces in a Vermont school,  Environ Sci Technol. 2023 Sep 26;57(38):14310-14318. doi: 10.1021/acs.est.3c05195. PMCID: PMC10537452 [Project 4, Analytical Core].  Dataset for this research.

Bannavti MK, Jahnke JC, Marek RF, Just CL, Hornbuckle KC, Congener-Specific Emissions from Floors and Walls Characterize Indoor Airborne PCBs. Environmental Science & Technology Letters, 2023 Aug 21;10(9):762-767.doi: 10.1021/acs.estlett.3c00360. eCollection 2023 Sep 12. PMCID: PMC10501191  [Project 4, Analytical Core]. Dataset for this research.

Bannavti MK, Jahnke JC, Marek RF, Just CL, Hornbuckle KC, Room-to-Room Variability of Airborne Polychlorinated Biphenyls in Schools and the Application of Air Sampling for Targeted Source Evaluation. Environ Sci Technol. 2021 Jul 20;55(14):9460-9468. doi: 10.1021/acs.est.0c08149. Epub 2021 May 25. Erratum in: Environ Sci Technol. 2021 Aug 3;55(15):10892. PMID: 34033460; PMC8427462, [Project 4, Analytical Core, CEC]. Dataset for this research.

Wang H, Adamcakova-Dodd A, Lehmler HJ, Hornbuckle KC, Thorne PS. Toxicity Assessment of 91-Day Repeated Inhalation Exposure to an Indoor School Air Mixture of PCBs. Environ Sci Technol. 2022 Feb 1;56(3):1780-1790. doi:10.1021/acs.est.1c05084. Epub 2022 Jan 7. PMID: 34994547; PMCID: PMC9122270 [Project 3, Project 4]  Dataset for this research.

Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov VE, Stolwijk JM, Lehmler HJ, Hornbuckle KC, Ludewig G, Robertson LW, Thorne PS. Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs. Environ Sci Technol. 2020 Dec 15;54(24):15976-15985. doi: 10.1021/acs.est.0c04470. Epub2020 Nov 30. PMID: 33256405; PMCID: PMC7879961. [Project 1, Project 4, Synthesis Core].  Dataset for this research

Rachel F Marek, Peter S Thorne, Nicholas J Herkert, Andrew M Awad, Keri C Hornbuckle, Airborne PCBs and OH-PCBs Inside and Outside Urban and Rural U.S. Schools, 2017 Jul 18;51(14):7853-7860.doi: 10.1021/acs.est.7b01910. [Analytical Core, Project 3, Project 4]. Dataset for this research.

 

 

Hui Wang, Amanda J Bullert, Xueshu Li, Hanna Stevens, Aloysius J Klingelhutz, James A Ankrum, Andrea Adamcakova-Dodd, Peter S Thorne, Hans-Joachim Lehmler, Use of a Polymeric Implant System to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol, a Human Metabolite of PCB 52, in Male Adolescent Rats, Toxicology, Volume 500, December 2023, 153677, PMCID:PMC10757425 [Project 1, Project 2, Project 3, Analytical Core, Synthesis Core]. The dataset has been released.

Paranjape, N., Dean, L.E., Martinez, A., Tjalkens, R.B., Lehmler, H.J., Doorn, J.A. (2023)  Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem. Res. Toxicol. Vol. 36, pp. 971-981, PMCID: PMC10283044 [Project 1, Project 4, Synthesis Core]. Dataset for this research.

Xueshu Li, Amanda J Bullert, Weiguo Han, Weizhu Yang, Qing-Yu Zhang, Xinxin Ding, Hans-Joachim Lehmler, Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice, Chem Res Toxicol. 2023 Aug 21;36(8):1386-1397, PMCID: PMC10445290 [Synthesis Core, Project 1, Univ. of Arizona, Analytical Core]. The dataset has been released.

Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler HJ. Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences, Environ Sci Technol. 2022 Jul 5;56(13):9515-9526. doi: 10.1021/acs.est.2c00581, PMCID: PMC9260965. [Synthesis Core, Analytical Core, DMAC] This dataset includes the information about samples from individual donors, including age, gender, and the weight of tissues used for this study.

Bullert AJ, Doorn JA, Stevens HE, Lehmler HJ. The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review. Chem Res Toxicol. 2021 Sep 20;34(9):1948-1952. doi: 10.1021/acs.chemrestox.1c00226. Epub 2021 Sep 7. PMID: 34491731; PMCID: PMC8456429. [Project 1]

Dataset:

Neha Paranjape, Stefan Strack, Hans-Joachim Lehmler, Jonathan A. Doorn; Dataset for Astrocyte Mitochondria are a Sensitive Target of PCB52 and its Human-relevant Metabolites; University of Iowa; 2024; DOI: 10.25820/data.007101 [Project 1]

Schrodt, M. V.; Behan-Bush, R. M.; Liszewski, J. N.; Humpal-Pash, M. E.; Boland, L. K.; Scroggins,S. M.; Santillan, D. A.; Ankrum, J. A., Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes, Stem Cell Res Ther, 14, 1, 206, PMC10433682, DOI: 10.1186/s13287-023-03443-z [Project 2]

Behan-Bush R. M., Liszewski J. N.,Schrodt M. V., Vats B., Li X., Lehmler H. J., Klingelhutz A. J.,Ankrum J. A., Toxicity Impacts on Human Adipose Mesenchymal Stem/Stromal Cells Acutely Exposed to Aroclor and Non-Aroclor Mixtures of Polychlorinated Biphenyl, Environ Sci Technol. 2023 Jan 31;57(4):1731-1742.,PMC9926300 [Project 2, Synthesis Core, Analytical Core]

Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Joachim-Lehmler H, Ankrum JA, Klingelhutz AJ. Transcriptome sequencing of 3,3',4,4',5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes. Toxicol In Vitro. 2022 Sep;83:105396. doi: 10.1016/j.tiv.2022.105396. Epub 2022 May 23. PMID: 35618242; PMCID: PMC9423686. [Project 2]

Datasets

Gourronc FA, Bullert A, Wang H, Helm-Kwasny BK, Chimenti M, Adamcakova-Dodd A, Jing X, Ankrum JA, Thorne PS, Lehmler H, Klingelhutz AJ, Effects of PCB52 exposure via Sub-Acute Nose-Only Inhalation on Gene Expression in Fat Depots of Adolescent Rats, GSE259369, NCBI Gene Expression Omnibus, March 4, 2024 [Project 2, Project 3, Synthesis Core]

Helm-Kwasny BK, Bullert A, Wang H, Chimenti M, Adamcakova-Dodd A, Jing X, Ankrum JA, Thorne PS, Lehmler H, Klingelhutz AJ, Effects of PCB52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Livers of Adolescent Rats, GSE255048, NCBI Gene Expression Omnibus, February 27, 2024 [Project 2, Project 3, Synthesis Core]

Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Joachim-Lehmler H, Ankrum JA, Klingelhutz AJ., Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126), Data in Brief. 2022 Sep 1;45:108571., doi: 10.1016/j.dib.2022.108571. PMC9483567 [Project 2]             

Jesse Liszewski, Aloysious Klingelhutz, Edward Sander, and James Ankrum, Dataset for development and analysis of scaffold-free adipose spheroids, University of Iowa, 02/08/2024 DOI: 10.25820/data.006816 [Project 2]

Amanda J Bullert, Xueshu Li, Binita Gautum, Hui Wang, Andrea Adamcakova-Dodd, Kai Wang, Peter S. Thorne, and Hans-Joachim Lehmler, Distribution of 2,2′,5,5′-Tetrachlorobiphenyl (PCB52) Metabolites in Adolescent Rats after Acute Nose-Only Inhalation Exposure, Environ. Sci. Technol. 2024,  58, 14, 6105-6116, PMCID: PMC11008251[Project 1, Synthesis Core, Project 3, DMAC]

Amanda Bullert, Xueshu Li, Zhang Chunyun, Kendra Lee, Casey F Pulliam, Brianna S Cagle, Jonathan A Doorn, Aloysius J Klingelhutz, Larry W Robertson, Hans-Joachim Lehmler, Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure, Environ Toxicol Pharmacol. 2023 Sep:102:104245, PMCID: PMC10562985 (available on 2024-09-01) [Project 1, Synthesis Core]. The dataset is now available.

Zhang CY, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler HJ, Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites, Environ Sci Technol, 2022 Sep 6; 56(17):12460-12472. doi: 10.1021/acs.est.2c03687, PMCID: PMC9573771. [Synthesis Core]

Zhang CY, Li X, Keil Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler HJ, Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples, Environ Sci Technol. 2022 Sep 20;56(18):13169-13178. PMCID: PMC9573770. [Synthesis Core, Analytical Core]. The dataset for the research has been released.

Zhang CY, Flor S, Ruiz P, Ludewig G, Lehmler HJ. Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites. Environ Sci Technol. 2021 Jul 6;55(13):9052-9062. PMCID: PMC8264946. [Synthesis Core]

Li X, Liu Y, Martin JW, Cui JY, Lehmler HJ. Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ- free and conventional mice, Environ Pollut. 2021 Jan 1;268(Pt A):115726. PMCID:PMC7746632. [Synthesis Core with the University of Washington SRP]. The dataset for the research has been released.

Saktrakulkla P, Dhakal RC, Lehmler HJ, Hornbuckle KC, A semi-target analytical method for quantification of OH-PCBs in environmental samples, Environ Sci Pollut Res Int. 2020 Mar; 27(9):8859-8871.  PMCID: PMC6986979 [Analytical Core, Synthesis Core]. The dataset for the research has been released.

Saktrakulkla P, Lan T, Hua J, Marek RF, Thorne PS, Hornbuckle KC., Polychlorinated Biphenyls in Food,  Environ Sci Technol. 2020 Sep 15;54(18):11443-11452. doi: 10.1021/acs.est.0c03632. Epub 2020 Sep 3. PMCID: PMC775 [Analytical Core, Project 3, Project 4] The study dataset has been released.

Jahnke JC, Hornbuckle KC. PCB Emissions from Paint Colorants. Environ Sci Technol. 2019 May 7;53(9):5187-5194. doi: 10.1021/acs.est.9b01087. Epub 2019 Apr, PMCID: PMC6519452. [Project 4, Analytical Core] The dataset from their research.

Jahnke JC, Martinez A, Hornbuckle KC. Distinguishing Aroclor and non-Aroclor sources to Chicago Air. Sci Total Environ. 2022 Jun 1;823:153263. Doi 10.1016/j.scitotenv.2022.153263. Epub 2022 Jan 21. PMID: 35066038; PMCID:  PMC9116205. [Project 4]. Dataset for this research.

Martinez A, Awad AM, Jones MP, Hornbuckle KC. Intracity occurrence and distribution of airborne PCB congeners in Chicago. Sci Total Environ. 2022 Mar 15;812:151505. doi: 10.1016/j.scitotenv.2021.151505. Epub 2021 Nov 8. PMCID: PMC8810667. [Project 4, DMAC]. Dataset for this research.

Andres Martinez, Andrew M. Awad, Nicholas J. Herkert, Keri C. Hornbuckle, Determination of PCB fluxes from Indiana Harbor and Ship Canal using dual-deployed air and water passive samplers, Environmental Pollution 244(2019) 469-476. [Project 4, Analytical Core] Dataset for this research.

Boesen AC, Martinez A, Hornbuckle KC,  Air-water PCB fluxes from southwestern Lake Michigan revisited. Environ Sci Pollut Res Int. 2020 Mar;27(9):8826-8834. doi: 10.1007/s11356-019-05159-1. Epub 2019 May 7. PMID: 31062242; PMCID: PMC6834886 [Project 4, Analytical Core]. Dataset for this research.

Wendy J. Heiger-Bernays, Kathryn Scott Tomsho, Komal Basra,  Zoe E. Petropoulos, Kathryn Crawford, Andres Martinez, Keri C. Hornbuckle, Madeleine K. Scammell, Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor, Science of the Total Environment 710 (2020) 135576. [Project 4 with Boston University SRP]. Dataset for this research.

Panithi Saktrakulkla, Xueshu Li, Andres Martinez, Hans-Joachim Lehmler, and Keri C. Hornbuckle, Hydroxylated Polychlorinated Biphenyls Are Emerging Legacy Pollutants in Contaminated Sediments, Environ Sci Technol. 2022 Feb 15; 56(4): 2269–2278. PMCID: PMC8851693 [Analytical Core, Synthesis Core, Project 4]. The study has released its dataset.    

Martinez A, Hua JBX, Haque E, Hornbuckle KC, Thorne PS. Occurrence and spatial distribution of individual polychlorinated biphenyl congeners in residential soils from East Chicago, southwest Lake Michigan. Sci Total Environ. 2022 Dec 1;850:157705. doi: 10.1016/j.scitotenv.2022.157705. PMCID: PMC9907466. [Project 3, Project 4]. This study has released is dataset.

Andres Martinez, Karin Norström, Kai Wang, and Keri C. Hornbuckle. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan, Environ Int. 2010 Nov; 36(8): 849–854, PMCID: PMC2888873 [Project 4, DMAC]. The dataset was released in 2019.

Andres Martinez, Douglas J. Schnoebelen, Keri C. Hornbuckle, Polychlorinated biphenyl congeners in sediment cores from the Upper Mississippi River, Chemosphere 144 (2016) 1943–1949, PMCID: PMC4695299  [Project 4]

Andres Martinez, Colin O’Sullivan, Danny Reible, Keri C. Hornbuckle, Sediment pore water distribution coefficients of PCB congeners in enriched black carbon sediment Environmental Pollution, 182 (2013) 357-363, PMCID: PMC3833079 [Project 4]

Andres Martinez, Nicholas R. Erdman, Zachary L. Rodenburg, Paul M. Eastling, Keri C. Hornbuckle, Spatial distribution of chlordanes and PCB congeners in soil in Cedar Rapids, Iowa, USA, Environmental Pollution, 161 (2012) 222-228, PMCID: PMC3255082 [Project 4]

Dingfei Hu, Andres Martinez, Keri C. Hornbuckle, Sedimentary records of non-Aroclor and Aroclor PCB mixtures in the Great Lakes, Journal of Great Lakes Research, 37 (2011) 359-364, PMCID: PMC3607302 [Project 4]

Andres Martinez, Karin Norström, Kai Wang, Keri C. Hornbuckle, Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan, Environment International, 36 (2010) 849-854, PMCID: PMC2888873  [Project 4]

Qin Dong, Gregory H. LeFevre, and Tim Mattes, Black Carbon Impacts on Paraburkholderia xenovorans Strain LB400 Cell Enrichment and Activity: Implications toward Lower-Chlorinated Polychlorinated Biphenyls Biodegradation Potential, Environ. Sci. Technol. 2024, 58, 8, 3895-30-7 [Project 5]

Hongyu Dang, Jessica M. Ewald, and Timothy E. Mattes, Genome-Resolved Metagenomics and Metatranscriptomics Reveal Insights into the Ecology and Metabolism of Anaerobic Microbial Communities in PCB-Contaminated Sediments, Environ Sci Technol. 2023 Oct 31; 57(43): 16386–16398. PMCID: PMC10621002 [Project 5] The dataset for this research has been released.

Bako CM, Martinez A, Marek RF, Hornbuckle KC, Schnoor JL, Mattes TE,  Lab-scale biodegradation assay using passive samplers to screen microorganisms for the ability to reduce PCB volatilization from contaminated sediment slurry to air. MethodsX, 2023 Jan 26;10:102039, doi: 10.1016/j.mex.2023.102039. eCollection 2023, PMC9926300 [Project 5, Project 4, Analytical Core]

Bako CM, Martinez A, Ewald JM, Hua JBX, Ramotowski DJ, Dong Q, Schnoor JL, Mattes TE. Aerobic Bioaugmentation to Decrease Polychlorinated Biphenyl (PCB) Emissions from Contaminated Sediments to Air. Environ Sci Technol. 2022 Oct 18;56(20):14338-14349. doi: 10.1021/acs.est.2c01043, PMCID: PMC9583607 [Project 5, Project 4]

Bako CM, Mattes TE, Marek RF, Hornbuckle KC, Schnoor JL. Biodegradation of PCB congeners by Paraburkholderia xenovorans LB400 in presence and absence of sediment during lab bioreactor experiments. Environ Pollut. 2021 Feb 15;271:116364. doi: 10.1016/j.envpol.2020.116364.  PMCID: PMC8183161. [Project 5, Analytical Core, Project 4]. The dataset has been released for the study.

Mattes TE, Ewald JM, Liang Y, Martinez A, Awad AM, Hornbuckle KC, Schnoor, JL. Microbial communities in polychlorinated biphenyl (PCB)-contaminated wastewater lagoon sediments: PCB congener, quantitative PCR, and 16S rRNA gene amplicon sequencing datasets. Data Brief. 2021 Nov 6;39:107546. doi: 10.1016/j.dib.2021.107546. PMCID: PMC8601980. [Project 5, Analytical Core]  The dataset has been released from the study. A second dataset from the study was also released.

Project 5 has developed more than 170 uncultured bacterium clones ribosomal RNA genes, partial sequences for their experiments. The full list can be found at the Iowa Superfund Research Program dataset on the NIEHS website.

Lehmler HJ, Uwimana E, Dean LE, Kovalchuk N, Zhang QY, Ding X. Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models. Chem Res Toxicol. 2022 Dec 19;35(12):2310-2323.  PMCID: PMC9957597. [Synthesis Core]

Li X, Lim JJ, Wang K, Prasad B, Bhatt DK, Cui JY, Lehmler HJ. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol. 2022 May; 92:103854. PMCID: PMC9090986.[Synthesis Core]. The datasets for the research have been released.

Li X, Zhang C, Wang K, Lehmler HJ. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut. 2020 Nov;266(Pt 1):115233. doi: 10.1016/j.envpol.2020.115233.Epub 2020 Jul 18. PMID: 32712482; PMCID: PMC7492420. [Project 1, Synthesis Core, DMAC]. The dataset for the research has been released.

 

In March 2023 the Synthesis Core released five Experimental Crystal Structure Determinations. These were created in collaboration with the University of Kentucky. They are:

DOI: 10.5517/ccdc.csd.cc2flz89,CCDC Number: 2252561

DOI: 10.5517/ccdc.csd.cc2flz9b,CCDC Number: 2252562

DOI: 10.5517/ccdc.csd.cc2flzbc,CCDC Number: 2252563

DOI: 10.5517/ccdc.csd.cc2flzcd,CCDC Number: 2252564

DOI: 10.5517/ccdc.csd.cc2flzdf,CCDC Number: 2252565

 

The Synthesis Core also released datasets that were synthesized as analytical standards to study the metabolism of PCB 11. The datasets can be found at:
Authentication of 5-bromo-3-chloro-1,2-dimethoxybenzenedoi.org/10.6084/m9.figshare.8269931.v1

Authentication_of_3_3_-dichloro-4_5-dimethoxy-biphenyl/8269832/1

 

In March 2020, they also released 12 datasets from previous publications regarding authentication of PCBs:

Authentication of 4-chloro-2-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10293434.v1

Authentication of 4-chloro-3-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10299302.v1

Authentication of 4-chloro-2'-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.8194220.v1

Authentication of 4-chloro-3'-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10295243.v1

Authentication of 4-chloro-4'-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10299173.v

Authentication of 4-chloro-3',4'-dihydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10295159.v1

Authentication of 4-chloro-3-fluoro-4'-hydroxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10295207.v1

Authentication of 4-chloro-2-methoxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10294895.v1

Authentication of 4-chloro-3-methoxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10295348.v1

Authentication of 4-chloro-2'-methoxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10293929.v1

Authentication of 4-chloro-3'-methoxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10299092.v1

Authentication of 4-chloro-4'-methoxy-biphenyl. 2020. DOI:10.6084/m9.figshare.10299209.v1

A complete list of all publications can be found at the NIEHS ISRP Publications page. A complete list of datasets can be found at the NIEHS ISRP Datasets page.