The Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome
Goal: Determine how airborne PCBs affect the development of metabolic syndrome (MetS) in adolescents.
MetS is a cluster of conditions that includes obesity, hypertension, dyslipidemia, and hyperglycemia, which increase the risk of heart disease, stroke, and type II diabetes.
1) Elucidate the functional consequences of airborne PCB exposure on adipogenesis and adipocyte function.
2) Develop a human adipose-liver biomimetic on-chip that allows for facile and accurate testing of the effects of environmental toxicants on adipose function.
3) Determine how airborne PCBs affect adiposity and metabolism.