Publications

2019

Boesen, A.C., Martinez, A., Hornbuckle, K.C., Air-water PCB fluxes from southwestern Lake Michigan revisited. Environmental Science and Pollution Research. 2019, DOI: 10.1007/s11356-019-05159-1. NIHMSID 1027870 [Project 4, Analytical Core]

Dhakal, R., S. Parkin, H.-J. Lehmler, 3,5-Dichloro-3',4'-dimethoxybiphenyl. IUCrData, 2019: Volume 4, Part 4, x190518. PMC Journal—in progress. [Synthesis Core]

Jahnke, J.C. and K.C. Hornbuckle, PCB emissions from paint colorants. Environmental Science and Technology, 2019, 53 (9), pp 5187–5194, doi: 10.1021/acs.est.9b01087. [Epub ahead of print]  NIHMSID 1027859 [Project 4, Analytical Core]

Janecheck, N.J.; Marek, R.F.; Bryngelson, N.; Singh, A.; Bullard, R.L.; Brune, W.H.; Stanier, C.O. Physical properties of secondary photochemical aerosol from OH oxidation of a cyclic siloxan. Atmospheric Chemistry and Physics, 2019.19, 1649-1664. DOI: 10.5194/acp-19-1649-2019, NIHMSID 1027995 [Analytical Core]

Li, X., X. Wu, K.M. Kelly, P. Veng-Pedersen, H.-J. Lehmler, Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chemical Research in Toxicology, 2019: 32, 727-736. PMC6465157 [Synthesis Core]

Liu, B., Sun, Y., Xu, G., Snetselaar, L. G., Ludewig, G., Wallace, R. B., Bao, W. (2019) Association between Body Iron Status and Leukocyte Telomere Length, a Biomarker of Biological Aging, in a Nationally Representative Sample of US Adults. Journal of the Academy of Nutrition and Dietetics, 119(4):617-625 doi:10.1016/j.jand.2018.09.007, NIHMS 1506894 [Project 1]

Sethi, S., Morgan, R., Feng, W., Lin, Y., Li, X., Luna, C., Koch, M., Bansal, R., Duffel, M.W., Puschner, B., Zoeller, T.R., Lehmler, H.J., Pessah, I.N., and Lein, P.J.  Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor.  Environmental Science and Technology, 2019. 53:3948-3958. PMC6457253 [Project 3, Synthesis Core in collaboration with UC-Davis Superfund Program]

Subramanian S, Tehrani R, Van Aken B, Transcriptomic response of Arabidopsis thaliana exposed to hydroxylated polychlorinated biphenyls (OH-PCBs), Int J Phytoremediation. 2019;21(1):52-59. doi: 10.1080/15226514.2018.1523872, PMCID:PMC6548195 [Available on 2020-01-16] [Project 5]

Uwimana, E., P. Ruiz, X. Li, H.-J. Lehmler, Human CYP2A6, CYP2B6 and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environmental Science and Technology, 2019: 53, 2114-2123. PMC6380921 [Synthesis Core]

Data

Boesen, A.C., Martinez, A., Hornbuckle, K.C., 2019. PCB congener data of gas-phase, dissolved water, meteorological conditions, and air-water PCB fluxes in southwestern Lake Michigan, 2010. PANGAEA. https://doi.org/10.1594/PANGAEA.897545 [Project 4, Analytical Core]

Martinez, A., Norström, K., Wang, K., Hornbuckle, K.C., 2019. Concentrations of individual polychlorinated biphenyl congeners and total organic carbon in surficial freshwater sediments from Indiana Harbor and Ship Canal, Indiana, USA. PANGAEA, https://doi.org/10.1594/PANGAEA.899695 [Project 4, Analytical Core]

2018

2018

Alam, S., G. Carter, K. Krager, X. Li, H.-J. Lehmler, and N. Aykin-Burns, PCB11 metabolite, 3,3’-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. 2018. 7(9): p. E121. PMC6162768. [Project 1 and Synthesis Core]

Cheng, S.L., X. Li, H.-J. Lehmler, B. Phillips, D. Shen, and J.Y. Cui, Gut Microbiota Modulates Interactions between Polychlorinated Biphenyls and Bile Acid Homeostasis. Toxicological Sciences, 2018. PMC6260149 [Synthesis Core]

Dhakal, K., G.S. Gadupudi, H.J. Lehmler, G. Ludewig, M.W. Duffel, and L.W. Robertson, Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environmental Science and Pollution Research International, 2018. 25(17): p. 16277-16290. PMC5785587. [Project 1, Project 3, Synthesis Core]

Duffel, M.W., Sulfotransferases, in Comprehensive Toxicology (Third Edition), C.A. McQueen, Editor. 2018, Elsevier: Oxford. p. 407-428. [Project 3]

Enayah, S.H., B.C. Vanle, L.J. Fuortes, J.A. Doorn, and G. Ludewig, PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology, 2018. 394: p. 93-101. PMC5756734. [Project 1]

Gadupudi, G.S., B.A. Elser, F.A. Sandgruber, X. Li, K.N. Gibson-Corley, and L.W. Robertson, PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver. Toxicological Sciences, 2018. 163(2): p. 440-453. PMC5974782. [Project 1, Synthesis Core]

Gourronc, F.A., L.W. Robertson, and A.J. Klingelhutz, A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environmental Science and Pollution Research International, 2018. 25(17): p. 16481-16492. PMC5764822. [Project 1, Synthesis Core]

Herkert, N.J. and K.C. Hornbuckle, Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environmental Science: Processes & Impacts, 2018. 20(5): p. 757-766. PMC5966328. [Project 4, Analytical Core]

Herkert, N.J., J.C. Jahnke, and K.C. Hornbuckle, Emissions of Tetrachlorobiphenyls (PCBs 47, 51, and 68) from Polymer Resin on Kitchen Cabinets as a Non-Aroclor Source to Residential Air. Environmental Science & Technology, 2018. 52(9): p. 5154-5160. PMC29667399. [Project 4, Analytical Core]

Herkert, N.J., S.N. Spak, A. Smith, J.K. Schuster, T. Harner, A. Martinez, and K.C. Hornbuckle, Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environmental Science: Processes & Impacts, 2018. 20(1): p. 210-219. PMC5783774. [Project 4, Analytical Core]

Jones, M.P., Linear regression with left-censored covariates and outcome using a pseudolikelihood approach. Environmetrics, 2018. 29(8): p. e2536. PMCID: PMC6344928  [Project 6]

Klaren, W.D., D. Vine, S. Vogt, and L.W. Robertson, Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environmental Science and Pollution Research International, 2018. 25(17): p. 16427-16433. PMC5866157. [Project 1, Synthesis Core with Argonne National Laboratories, KC Donnelly]

Klinefelter, K., M.K. Hooven, C. Bates, B.T. Colter, A. Dailey, S.K. Infante, I. Kania-Korwel, H.J. Lehmler, A. Lopez-Juarez, C.P. Ludwig, and C.P. Curran, Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mammalian Genome, 2018. 29(1-2): p. 112-127.PMCID: PMC6425730   [Project 1 and Synthesis Core]

Li, X., E.B. Holland, W. Feng, J. Zheng, Y. Dong, I.N. Pessah, M.W. Duffel, L.W. Robertson, and H.J. Lehmler, Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environmental Science and Pollution Research International, 2018. 25(17): p. 16508-16521. PMC6015536. [Synthesis Core in collaboration with the UC Davis Superfund Research Program]

Li, X., S.R. Parkin, and H.J. Lehmler, Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environmental Science and Pollution Research International, 2018. 25(17): p. 16402-16410. PMC5823790. [Synthesis Core]

Liu, Y., E.S. Richardson, A.E. Derocher, N.J. Lunn, H.J. Lehmler, X. Li, Y. Zhang, J.Y. Cui, L. Cheng, and J.W. Martin, Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. Angewandte Chemie (International Ed. in English), 2018. 57(50): p. 16401-16406, PMCID: PMC6394828 [Available on 2019-12-10] [Synthesis Core]

Martinez, A., A.M. Awad, N.J. Herkert, and K.C. Hornbuckle, Determination of PCB fluxes from Indiana Harbor and Ship Canal using dual-deployed air and water passive samplers. Environmental Pollution, 2019. 244: p. 469-476. PMC6277018. [Project 4, Analytical Core]

Mattes, T.E., J.M. Ewald, Y. Liang, A. Martinez, A. Awad, P. Richards, K.C. Hornbuckle, and J.L. Schnoor, PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon. Environmental Science and Pollution Research, 2018. 25(17): p. 16376-16388. PMC6206866. [Project 4, Project 5, Analytical Core]

Parker, V.S., E.J. Squirewell, H.J. Lehmler, L.W. Robertson, and M.W. Duffel, Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environmental Toxicology and Pharmacology, 2018. 58: p. 196-201. PMC6078096. [Projects 3, Synthesis Core]

Pencikova, K., P. Brenerova, L. Svrzkova, E. Hruba, L. Palkova, J. Vondracek, H.J. Lehmler, and M. Machala, Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environmental Science and Pollution Research International, 2018. 25(17): p. 16411-16419. PMC5943194. [Synthesis Core]

Pencikova, K., L. Svrzkova, S. Strapacova, J. Neca, I. Bartonkova, Z. Dvorak, M. Hyzdalova, J. Pivnicka, L. Palkova, H.J. Lehmler, X. Li, J. Vondracek, and M. Machala, In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environmental Pollution, 2018. 237: p. 473-486. PMC5908724. [Synthesis Core]

Rodriguez, E.A., B.C. Vanle, J.A. Doorn, H.J. Lehmler, L.W. Robertson, and M.W. Duffel, Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environmental Toxicology and Pharmacology, 2018. 62: p. 69-78. PMC6092199. [Project 3, Synthesis Core]

Sethi, S., K.P. Keil, and P.J. Lein, 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Archives of Toxicology, 2018. PMC6196112   [Synthesis Core]

Tomsho, K.S., K. Basra, S.M. Rubin, C.B. Miller, R. Juang, S. Broude, A. Martinez, K.C. Hornbuckle, W. Heiger-Bernays, and M.K. Scammell, Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environmental Science and Pollution Research, 2018. 25(17): p. 16389-16400. PMC6015112. [Project 4 in collaboration with the Boston University Superfund Research Program]

Uwimana, E., X. Li, and H.-J. Lehmler, Human liver microsomes atropselectively metabolize 2,2',3,4',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environmental Science & Technology, 2018. 52(10): p. 6000-6008. PMC5966832. [Synthesis Core]

Data

Martinez, A., A.M. Awad, N.J. Herkert, and K.C. Hornbuckle, PCB congener data of gas-phase, freely-dissolved water, air-water fugacity ratios and air-water fluxes in Indiana Harbor and Ship Canal, IN,U.S., 2018, PANGAEA. 10.1594/PANGAEA.894908. [Project 4, Analytical Core]

2017

Grimm FA, Lehmler HJ, Koh WX, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW, Identification of a sulfate metabolite of PCB 11 in human serum, Environ Int. 2017 Jan;98:120-128. PMCID: PMC5127762 [Projects 1, 3, and 6, Synthesis Core, Analytical Core, and Community Engagement Core]

E.B. Holland, W. Feng, J. Zheng, Y. Dong, X. Li, H.-J. Lehmler, I.N. Pessah, An extended structure-activity relationship of non-dioxin like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Tox. Sci. 2017: 155, 170-181. PMCID: PMC5216651. [Synthesis Core and collaboration with the UC Davis Superfund]

Kalkunte S, Huang Z1, Lippe E, Kumar S, Robertson LW, Sharma S. Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep. 2017 Jan 10;7:39885. doi: 10.1038/srep39885, PMCID: PMC5223111[Synthesis Core and Project 1 and collaboration with the Brown Superfund]

I. Kania-Korwel, T. Lukasiewicz, C.D. Barnhart, M. Stamou, H. Chung, K.M. Kelly, S. Bandiera, P.J. Lein, H.-J. Lehmler, Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Tox. Sci. 2017 Jul 1;158(1):101-115. PMCID: PMC6070089  [Synthesis Core and collaboration with UC Davis]

Kania-Korwel I, Wu X, Wang K, Lehmler HJ, Identification of Lipidomic Markers of Chronic 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Exposure in the Male Rat Liver. Toxicology. 2017 Sep 7. pii: S0300-483X(17)30250-0. doi: 10.1016/j.tox.2017.09.005.  PMCID: PMC5633524 [Synthesis Core, KC Donnelly]

Li YL, Hou XW, Yu M, Zhou QF, Liu JY, Schnoor JL, Jiang GB, Dechlorination and chlorine rearrangement of 1,2,5,5,6,9,10-heptachlorodecane mediated by whole pumpkin seedlings. Environmental Pollution 2017 224:524-531. https://doi.org/10.1016/j.envpol.2017.02.035. PMCID:PMC6351073 [Project 5 and collaboration with the Research Center for EcoEnvironmental Science, Chinese Academy of Science, Beijing]

Qian, J.J., B. Jennings, D.M. Cwiertny, and A. Martinez, Emerging investigator series: development and application of polymeric electrospun nanofiber mats as equilibrium-passive sampler media for organic compounds. Environmental Science: Processes & Impacts, 2017. 19(11): p. 1445-1456. PMC5687983. [Project 4]

S. Liu, H. Zhao, H-J. Lehmler, X. Cai, J. Chen, Antibiotic pollution in marine food webs in Laizhou Bay, North China: Trophodynamics and human exposure implication. Environ. Sci. Technol. 2017: 51, 2392-2400. PMCID:PMC5618103 [Synthesis Core and collaboration with the Dalian University of Technology, PR China]

Marek RF, Thorne PS1, Herkert NJ, Awad AM, Hornbuckle KC, Airborne PCBs and OH-PCBs Inside and Outside Urban and Rural U.S. Schools, Environ Sci Technol. 2017 Jul 18;51(14):7853-7860. PMCID:PMC5777175 [Projects 4,6 and the Analytical, Synthesis and Community Engagement Cores]

Martinez A, Hadnott BN, Awad AM, Herkert NJ, Tomsho K, Basra K, Scammell MK, Heiger-Bernays W, Hornbuckle KC, Release of Airborne Polychlorinated Biphenyls from New Bedford Harbor Results in Elevated Concentrations in the Surrounding Air, Environ Sci Technol Lett. 2017 Apr 11;4(4):127-131. PMCID: PMC5390305  [Project 6, Project 4, Analytical Core, Synthesis Core, Community Engagement Core in collaboration with Boston University Superfund Research Program]

Mattes TE, Ewald JM, Liang Y, Martinez A, Awad A, Richards P, Hornbuckle KC, Schnoor JL, PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon, Environ Sci Pollut Res Int. 2017 Aug 12.  PMCID: PMC6206866 [Projects 4 and 5 and the Analytical Core]

Roh T, Lynch CF, Weyer P, Wang K, Kelly KM, Ludewig G. Low-level arsenic exposure from drinking water is associated with prostate cancer in Iowa. Environ Res. 2017;159:338-43. PMCID:PMC5623650 [Project 1 and Training Core]   

H.W. Schroer, K.L. Langenfeld, X. Li, H.-J. Lehmler, C.L. Just, Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 2017: 28, 95-109. PMCID:PMC5772970 [Synthesis Core, Analytical Core]

Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicol Sci. 2017 Aug 1;158(2):401-411.PMCID: PMC5837364  [Synthesis Core and collaboration with UC Davis]

Subramanian S, Schnoor JL, Van Aken B, Effects of Polychlorinated Biphenyls (PCBs) and Their Hydroxylated Metabolites (OH-PCBs) on Arabidopsis thaliana. Environ Sci Technol. 2017 Jun 20;51(12):7263-7270. PMCID:PMC5772893   [Project 5 and Synthesis Core]

E. Uwimana, A. Maiers, X. Li, H.-J. Lehmler, Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ. Sci. Technol. 2017: 51, 1820-1829. PMCID: PMC5300040. [Projects 3 and 5, Synthesis Core]

Xiao, X., B. Chen, L. Zhu, and J.L. Schnoor, Sugar Cane-Converted Graphene-like Material for the Superhigh Adsorption of Organic Pollutants from Water via Coassembly Mechanisms. Environmental Science & Technology, 2017. 51(21): p. 12644-12652. PMCID: PMC6434681

2016

Anderson, D.G., V.R. Florang, J.H. Schamp, G.R. Buettner, and J.A. Doorn, Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite. Chemical Research in Toxicology, 2016. 29(7): p. 1098-107. PMC5248556. [Project 1]

Awad, A.M., A. Martinez, R.F. Marek, and K.C. Hornbuckle, Occurrence and Distribution of Two Hydroxylated Polychlorinated Biphenyl Congeners in Chicago Air. Environmental Science & Technology Letters, 2016. 3(2): p. 47-51, PMCID: PMC6148743 [Project 4, Analytical Core, Synthesis Core]

Bhalla, R., R. Tehrani, and B. Van Aken, Toxicity of hydroxylated polychlorinated biphenyls (HO-PCBs) using the bioluminescent assay Microtox®. Ecotoxicology, 2016. 25(7): p. 1438-1444. PMC5131519. [Project 5]

Doskey, C.M., V. Buranasudja, B.A. Wagner, J.G. Wilkes, J. Du, J.J. Cullen, and G.R. Buettner, Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biology, 2016. 10: p. 274-284. PMC5106370. [Project 1]

Ekuase EJ, van 't Erve TJ, Rahaman A, Robertson LW, Duffel MW, Luthe G. Mechanistic Insights into the Specificity of Human Cytosolic Sulfotransferase 2A1 (hSULT2A1) for Hydroxylated Polychlorinated Biphenyls Through the Use of Fluoro-tagged Probes Environ Sci Pollut Res 23, 2119-2127, 2016, PMCID: PMC4713379.  [Project 1, Project 3, Synthesis Core]

Flor, S., X.R. He, H.J. Lehmler, and G. Ludewig, Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells. Environmental Science and Pollution Research, 2016. 23(3): p. 2186-2200. PMC4718780. [Project 1, Synthesis Core]

Gadupudi GS, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol. 2016  Sep 19;29(9):1504-9 [Project 1, Synthesis Core]

Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW, PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats. Toxicological Sciences 2016 Jan;149(1):98-110, PMID:26396156, PMCID:PMC4731404 [Project 1, Synthesis Core]

Herkert, Nicholas J, Martinez, Andres, Hornbuckle, Keri C, A Model Using Local Weather Data to Determine the Effective Sampling Volume for PCB Congeners Collected on Passive Air Samplers. Environmental science & technology, 2016 July, 50:6690-7, PMID 26963482, PMCID: PMC4935961  [Project 4, Analytical Core]

Gary Hunt, John Stegeman, Larry Robertson. PCBs: exposures, effects, remediation, and regulation with special emphasis on PCBs in schools. Environ Sci Pollut Res 23, 1971-1974, 2016, PMCID: PMC4718839  [Administrative Core in collaboration with Boston University Superfund Research Program]

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Polychlorinated Biphenyls and Polybrominated Biphenyls. IARC monographs on the evaluation of carcinogenic risks to humans, 2016. 107: p. 9-500. PMID29905442. [Project 1]

Kania-Korwel, I. and H.J. Lehmler, Chiral polychlorinated biphenyls: absorption, metabolism and excretion - a review. Environmental Science and Pollution Research, 2016. 23(3): p. 2042-2057. PMC4527964. [Synthesis Core]

Kania-Korwel, I. and H.J. Lehmler, Toxicokinetics of chiral polychlorinated biphenyls across different species - a review. Environmental Science and Pollution Research, 2016. 23(3): p. 2058-2080. PMC4591098. [Synthesis Core]

Klaren WD, Flor S, Gibson-Corley KN, Ludewig G, Robertson LW. Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicology Reports 3, 21-28 (2016), PMCID: PMC4710377. [Project 1, Synthesis Core]

Klaren WD, Gibson-Corley K, Wels B, Simmons D, McCormick M, Spitz DR, Robertson LW. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol. 29, 851-859, 2016,PMCID:PMC5100827 [Project 1, Synthesis Core]

Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities. Chemosphere. 2016 Mar:147:389-95, PMID: 26774304, PMCID: PMC4747419 [Project 1, Synthesis Core]

Koh, W.X., K.C. Hornbuckle, K. Wang, and P.S. Thorne, Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers. Environment International, 2016. 94: p. 538-545. PMC4980156. [Project 6, Analytical Core, Synthesis Cores]

Li M, Teesch LM, Murry DJ, Pope RM, Li Y, Robertson LW, Ludewig G. Cytochrome c adducts with PCB quinoid metabolites. Environ Sci Pollut Res 23, 2148-2159, 2016, PMID: 26062463, PMCID: PMC4676959. [Project 1, Synthesis Core]

Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler HJ, Schnoor JL, Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants, Environ Sci Pollut Res Int. 2016 Feb;23(3):2089-98, PMID:26676542, PMCID: PMC4718877  [Project 5, Analytical Core, Synthesis Core]

Martinez, A., D.J. Schnoebelen, and K.C. Hornbuckle, Polychlorinated biphenyl congeners in sediment cores from the Upper Mississippi River. Chemosphere, 2016. 144: p. 1943-1949. PMC4695299. [Project 4, Analytical Core]

D. Osterberg and M.K.Scammell (2016). PCBs in schools—where communities and science come together. Environ. Sci. Pollut. Res. Int. 23(3), 1998-2002,  PMCID: PMC4770789 DOI: 10.1007/s11356-015-5009-2 [Research Translation Core, Community Engagement Core in collaboration with Boston University Superfund Research Program]

Christopher J Portier, Bruce Armstrong, Bruce C Baguley, Xaver Baur, Igor Belyaev, Robert Bellé, Fiorella Belpoggi, Annibale Biggeri, Maarten C Bosland, Paolo Bruzzi, Lygia Therese Budnik, Merete D Bugge, Kathleen Burns, Gloria M Calaf, David O Carpenter, Hillary M Carpenter, Lizbeth López-Carrillo, Richard Clapp, Pierluigi Cocco, Dario Consonni, Pietro Comba, Elena Craft, Mohamed Aqiel Dalvie, Devra Davis, Paul A Demers, Anneclaire De Roos, Jamie DeWitt, Francesco Forastiere, Jonathan H Freedman, Lin Fritschi, Caroline Gaus, Julia M Gohlke, Marcel Goldberg, Eberhard Greiser, Johnni Hansen, Lennart Hardell, Michael Hauptmann, Wei Huang, James Huff, Margaret O James, C W Jameson, Andreas Kortenkamp, Annette Kopp-Schneider, Hans Kromhout, Marcelo L Larramendy, Philip J Landrigan, Lawrence H Lash, Dariusz Leszczynski, Charles F Lynch, Corrado Magnani, Daniele Mandrioli, Francis L Martin, Enzo Merler, Paola Michelozzi, Lucia Miligi, Anthony B Miller, Dario Mirabelli, Franklin E Mirer, Saloshni Naidoo, Melissa J Perry, Maria Grazia Petronio, Roberta Pirastu, Ralph J Portier, Kenneth S Ramos, Larry W Robertson, Theresa Rodriguez, Martin Röösli, Matt K Ross, Deodutta Roy, Ivan Rusyn, Paulo Saldiva, Jennifer Sass, Kai Savolainen, Paul T J Scheepers, Consolato Sergi, Ellen K Silbergeld, Martyn T Smith, Bernard W Stewart, Patrice Sutton, Fabio Tateo, Benedetto Terracini, Heinz W Thielmann, David B Thomas, Harri Vainio, John E Vena, Paolo Vineis, Elisabete Weiderpass, Dennis D Weisenburger, Tracey J Woodruff, Takashi Yorifuji, Il Je Yu, Paola Zambon, Hajo Zeeb, Shu-Feng Zhou. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). Journal of Epidemiology & Community Health 70, 741-745, 2016, PMCID: PMC 4975799. [Project 1]

Rodriguez, Eric, Li, Xueshu, Lehmler, Hans-Joachim, Robertson, Larry, and Duffel, Michael. Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin. Environmental Science & Technology 50, 5320-5327, 2016, PMCID: PMC 4883002. [Project 1, Project 3, Synthesis Core]

Shen H, Robertson LW, Ludewig G. Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3. Environ Sci Pollut Res. 23, 2108-2118, 2016, PMID: PMCID: PMC4662644. [Project 1, Synthesis Core]

Aditya Stanam, Katherine N. Gibson-Corley, Laurie Love-Homan, Nnamdi Ihejirika, Andrean L. Simons. Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma. Octotarget; October 12, 2016.pp 1-14. DOI: 10.18632/oncotarget.12590, PMCID:PMC5342798 [Analytical Core]

E. Uwimana, X. Li, H.-J. Lehmler, 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para hydroxylated metabolites by human liver microsomes. Chem. Res. Toxicol. 2016: 29, 2108-2110. PMCID: PMC5175585. [Projects 3 and 5 and the Synthesis Core]

Wang B, Klaren WD, Wels BR, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G, Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat, Toxicol Sci. 2016 Mar;150(1):15-26, PMID: 26660635, PMCID: PMC5009614 [Project 1, Synthesis Core]

Wangpradit O, Adamcakova-Dodd A, Heitz K, Robertson L, Thorne PS, Luthe G. PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats. Environ Sci Pollut Res 23, 2128-2137, 2016, PMID: 26400242, PMCID: PMC4803647

Wangpradit O, Rahaman A, Mariappan SV, Buettner GR, Robertson LW, Luthe G. Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids. Environ Sci Pollut Res 23, 2138-2147, 2016, PMCID: PMC4767158 [Project 1, Project 7, Synthesis Core]

Wu X, Lehmler HJ., Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes, Environ Sci Pollut Res Int. 2016 Feb;23(3):2081-8, PMCID:PMC4706823 [Synthesis Core]

Wu X, Yang J, Morisseau C, Robertson LW, Hammock B, Lehmler HJ., 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats, Toxicol Sci. 2016 Aug;152(2):309-22, PMCID: PMC4960907 [Project 1, Synthesis Core in collaboration with UC Davis Superfund, KC Donnelly Award]

Xiao, W., E.H. Sarsour, B.A. Wagner, C.M. Doskey, G.R. Buettner, F.E. Domann, and P.C. Goswami, Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Archives of Toxicology, 2016. 90(2): p. 319-332. PMC4441874. [Project 2, Synthesis Core]

Xin X, Senthilkumar PK, Schnoor JL, Ludewig G. (2016). Effects of PCB126 and PCB153 on telomerase activity and telomere length in undifferentiated and differentiated HL-60 cells. Environmental Science and Pollution Research International 23, 2173-2185. PMCID: PMC4718801 [Project 1, Project 5, Synthesis Core]

 

2015

Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol. 49, 1156-64 (2015), PMID: 25510359, PMCID:PMC4303332[Project 7, Project 4, and Analytical Core]

Doskey CM, van 't Erve TJ, Wagner BA, Buettner GR. Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture. PLoS One. 10, e0132572 (2015), PMID: 2617283, PMCID: PMC4501792 [Project 1]

Gadupudi, Gopi, Francoise A. Gourronc, Gabriele Ludewig, Larry W. Robertson and Aloysius J. Klingelhutz. PCB126 Inhibits Adipogenesis of Human Preadipocytes. Toxicology in Vitro 29, 132-41 (2015), PMID: 25304490, PMCID: PMC4250299. [Project 1 and Synthesis Core]

Grimm, Fabian, Robertson, Larry, Lehmler, Hans-Joachim, Duffel, Michael W. Modulating Inhibitors of Transthyretin Fibrillogenesis via Sulfation: Polychlorinated Biphenyl Sulfates as Models. Chem.-Biol. Interactions 228, 1-8 (2015), PMID: 25595224, PMCID: PMC4327905 [Project 3, Project 1, and the Synthesis Core]

Grimm FA, He X, Teesch LM, Lehmler HJ, Robertson LW, Duffel MW. Tissue Distribution, Metabolism, and Excretion of 3, 3’-Dichloro-4'-sulfooxy-biphenyl in the Rat. Environ Sci. Technol. 49, 8087-8095 (2015), PMID: 26046945, PMCID: PMC4496304.[Project 3, Project 1, and Synthesis Core]

Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW, Metabolism and metabolites of polychlorinated biphenyls (PCBs). Critical Reviews in Toxicology 45, 245-72 (2015), PMID: 25629923, PMCID: PMC4383295.[All Projects and Cores]

Hu X, Adamcakova-Dodd A, Lehmler HJ, Gibson-Corley KN, Thorne PS. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ. Sci. Technol.2015:49,11875-83.PMID:26348937, PMCID: PMC4711378.[Project 7 and Synthesis Core]

Jones, M.P., S.S. Perry, and P.S. Thorne, Maximum Pairwise Pseudo-likelihood Estimation of the Covariance Matrix from Left-Censored Data. Journal of Agricultural, Biological, and Environmental Statistics, 2015. 20(1): p. 83-99. PMCID: PMC6326180 [Project 6]

I. Kania-Korwel, C.D. Barnhart, P.J. Lein, H.-J. Lehmler, Effect of pregnancy on the disposition of 2, 2’, 3, 5’, 6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem. Res. Toxicol. 2015:28, 1174-83. PMID:26271003, PMCID:PMC4579038 [Projects 3, 5 and Synthesis Core]

William Klaren, Gopi Gadupudi, Brian Wels, Donald Simmons, Alicia Olivier, and Larry W. Robertson. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Toxicology, 2015, 3381-7. PMID: 26419179, PMCID: PMC4658301 [Project 1]

Koh WX, Hornbuckle KC, Thorne PS. Human Serum from Urban and Rural Adolescents and Their Mothers Shows Exposure to Polychlorinated Biphenyls Not Found in Commercial Mixtures. Environ Sci Technol. 49, 8105-12 (2015), PMID: 26053216, PMCID: PMC4774248
[Projects 4, 6 and Analytical Core]

Liang, Y., R. Meggo, D. Hu, J.L. Schnoor, and T. E. Mattes. Microbial community analysis of switchgrass planted and unplanted soil microcosms displaying PCB dechlorination. (2015) Appl Microbiol Biotechnol 99: 6515-6526. PMID: 25820643, PMCID: PMC4498989 [Project 5]

Martinez, A., S.N. Spak, N.T. Petrich, D.F. Hu, G.R. Carmichael, and K.C. Hornbuckle, Atmospheric dispersion of PCB from a contaminated Lake Michigan harbor. Atmospheric Environment, 2015. 122: p. 791-798. PMC4649934. [Project 4, Analytical Core]

Oldham, E.D., L.M. Nunes, A. Varela-Ramirez, S.E. Rankin, B.L. Knutson, R.J. Aguilera, H.-J. Lehmler, Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line. Chem. Cent. J. 2015: 9:3. PMID: 25705252, PMCID: PMC4333309.[Synthesis Core]

Peverly, A.A., Y. Ma, M. Venier, Z. Rodenburg, S.N. Spak, K.C. Hornbuckle, and R.A. Hites, Variations of Flame Retardant, Polycyclic Aromatic Hydrocarbon, and Pesticide Concentrations in Chicago's Atmosphere Measured using Passive Sampling. Environmental Science & Technology, 2015. 49(9): p. 5371-5379. PMCID: PMC6314031[Project 4 in collaboration with Indiana University]

Peverly AA, O'Sullivan C, Liu LY, Venier M, Martinez A, Hornbuckle KC, Hites RA. Chicago's Sanitary and Ship Canal sediment: Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters. Chemosphere 134, 380-6 (2015), PMID: 25981316 [Project 4]

van't Erve TJ, Wagner BA, Martin SM, Knudson CM, Blendowski R, Keaton M, Holt T, Hess JR, Buettner GR, Ryckman KK, Darbro BW, Murray JC, Raife TJ. (2015) The heritability of hemolysis in stored human red blood cells. Transfusion. 2015 Feb 2. PMID: 25644965, PMCID: PMC4469565 [Project 1]

Wu, X., C. Barnhart, P.J. Lein, H.-J. Lehmler, Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ. Sci. Technol. 49:616-625 (2015), PMID: 25420130,PMCID: PMC4291784.[Projects 3, 5 and Synthesis Core]

Zhao, H.X., J.Q. Jiang, Y.L. Wang, H.J. Lehmler, G.R. Buettner, X. Quan, and J.W. Ghen, Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol. Environmental Science & Technology, 2015. 49(24): p. 14120-14128. PMCID: PMC4717839. [Synthesis Core]

2014

Aqil, F., H. Shen, J. Jeyabalan, X. Xin, H.J. Lehmler, G. Ludewig, L.W. Robertson, and R.C. Gupta, Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicology Reports, 2014. 1: p. 820-833. PMC4266188. [Project 1, Synthesis Core]

Dhakal, K., Uwimana, E., Adamcakova-Dodd, A., Thorne, P.S., Lehmler, H., Robertson, L.W. (2014) Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chemical Research in Toxicology, 2014 Jul 15. [Epub ahead of print], PMID: 24988477, PMCID:PMC4137987 [Project 1, Inhalation Toxicology Core and Synthesis Core]

Ekuase, E.J., Lehmler, H.-J., Robertson, L.W. Duffel, M.W. (2014) Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chemico-Biological Interactions, 212 56-64. PMID: 24508592, PMCID: PMC3994546 [Project 3]

Hu, X., Adamcakova-Dodd, A., and Thorne, P.S. (2014) The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environment International, 63 92-100. PMID: 24275706, PMCID: PMC3950335 [Inhalation Toxicology Core (now Project 7) and Synthesis Core]

Kim, J.S. Klösener, J., Flor, S., Peters, T.M., Ludewig, G., Thorne, P.S., Robertson, L.W., Luthe, G. (2014) Toxicity assessment of air-delivered particle-bound polybrominated diphenyl ethers. Toxicology, 317 31–39. PMID: 24451063, PMCID: PMC3975599 [Project 1 and Inhalation Toxicology Core (now Project 7)]

Li, X., Parkin, S., Lehmler, H.-J. (2014) 2,4-Dichloro-1-iodo-6-nitrobenzene. Acta Crystallographica, E70, o607. PMID: 24860400, PMCID: PMC4011245 [Synthesis Core]

Liang, Y., Martinez, A., Hornbuckle, K.C., Mattes, T.E. (2014). Potential for polychlorinated biphenyl biodegradation in sediments from Indiana harbor shipping canal. International Biodeterioration and Biodegradation, 89 50-57. PMID:24764649, PMCID:PMC3993986, [Project 5, Project 4, and Analytical Core]

Marek, R.F., P.S. Thorne, J. DeWall, and K.C. Hornbuckle, Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural U.S. communities. Environmental Science & Technology, 2014. 48(22): p. 13459-13467. PMC4238695. [Project 4, Project 6, Analytical Core, Synthesis Cores]

Narbonne, J. and Robertson, L. W. (2014) 7th International PCB Workshop: Chemical mixtures in a complex world. Environmental Science and Pollution Research 21, 6269-6275. PMID: 24627200 PMCID: PMC4024085 [Administrative Core]

Salman, K.N., Stuart, M.A., Schmidt, J., Borges, H.T., McClain, C.J., Robinson, F.R., Li, M., and Robertson, L.W. (2014) The effects of 3,3’,4,4’-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum, Environmental Science and Pollution Research 21, 6400-6409. PMID: 23532536 PMCID: PMC3732555 [Project 1]

Sarsour, E.H., Kalen, A.L. Goswami, P.C. (2014) Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxidants & Redox Signaling, 20(10) 1618-27. PMID: 23590434, PMCID: PMC 3942678 [Project 2]

Shen, H., Li, M., Wang, B., Lai, I. K., Robertson, L.W., Ludewig, G. Dietary antioxidants (selenium & N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB126-exposed rats. Environmental Science and Pollution Research 21, 6384-6399. PMID: 23644946, PMCID: PMC3769429 [Project 1]

Stamou, M., Wu, X., Kania-Korwel, I., Lehmler, H-J., Lein, P.J. (2014) Cytochrome P450 mRNA expression in the rodent brain: species-, sex- and region-dependent differences. Drug Metabolism and Disposition, 42 239-244. PMID: 24255117, PMCID: PMC3912540 [Synthesis Core]

Staudt, S., Kundu, S., Lehmler, H.-J., He, X., Cui, T., Lin, Y.-H., Kristensen, K., Glasius, M., Zhang, X., Weber, R.J., Surratt, J.D., Stone, E.A. (2014) Aromatic organosulfates in atmospheric aerosols: Synthesis, characterization, and abundance.Atmospheric Environment, 94 366-373.PMID:24976783, PMCID: PMC4071301 [Synthesis Core]

Sueyoshi, T., Li, L., Wang, H., Moore, R., Kodavanti, P.R.S., Lehmler, H.-J., Negishi, M.and Birnbaum, L. (2014) Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicological Sciences, 137 292-302.PMID:24218150, PMCID: PMC3908718 [Synthesis Core]

van ‘t Erve, T.J., Wagner, B.A., Martin, S.M., Knudson, C.M., Blendowski, R., Keaton, M., Holt, T., Hess, J.R., Buettner, G.R., Rykman, K.K., Darbro, B.W., Murray, J.C., Raife, T.J. (2014) The heritability of metabolite concentrations in stored human red blood cells. Transfusion. PMID: 24601981,PMCID: PMC4138246 [Project 1]

Vorrink, S.U., Severson, P.L., Kulak, M.V., Futscher, B.W., Domann, F.E. (2014) Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicology and Applied Pharmacology 274, 408-416. PMID:24355420 PMCID: PMC3919493 [Project 2 and Synthesis Core]

Vorrink, S.U; Goswami, P., Sarsour, E., Olivier, A.K., Robertson, L.W., Domann, F. (2014) PCB 126 perturbs hypoxia induced Hif-1α activity and glucose consumption in human HepG2 cells. Experimental and Toxicologic Pathology, In Press. PMID: 24916446, PMCID: PMC4143452
[Project 2 and Project 1]

Wu, X., Kammerer, A., Lehmler, H-J. (2014) Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environmental Science and Technology, 48 2436-44. PMCID: PMC3983324 [Synthesis Core]

Yang, D., Kania-Korwel, I., Ghogha, A., Chen, H., Stamou, M., Bose, D.D., Pessah, I.N., Lehmler, H-J., Lein, P.J. (2014) PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicological Sciences, 138 379-392. PMCID: PMC4007107 [Synthesis Core] This article was the Editor’s Highlight in the April 2014 issue of Toxicological Sciences.

Zhai, G., S.M. Gutowski, H.J. Lehmler, and J.L. Schnoor, Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants. Environmental Science & Technology, 2014. 48(20): p. 12213-12220. PMC4207536. [Project 5, Synthesis Core]

2013

Dhakal K, Adamcakova-Dodd A, Lehmler HJ, Thorne PS, Robertson LW. Sulfate Conjugates Are Urinary Markers of Inhalation Exposure to 4-Chlorobiphenyl (PCB3). Chem Res Toxicol. 2013 Jun 17;26(6):853-5. doi: 10.1021/tx4001539. Epub 2013 May 28. PubMed PMID: 23713983; PubMed Central PMCID: PMC3703249.

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW, Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin. Environ Health Perspect. 2013 Apr 12. 121:657-662. PMID: 23584369 PMCID: PMC3672920.

Kania-Korwel I, Lehmler HJ. Chlordane and Heptachlor Are Metabolized Enantioselectively by Rat Liver Microsomes. Environ Sci Technol. 2013 Jul 10. [Epub ahead of print] PubMed PMID: 23799267. NIHMS ID: NIHMS500524

Kania-Korwel I, Lehmler HJ. Assigning atropisomer elution orders using atropisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism. J Chromatogr A. 2013 Feb 22;1278:133-44. doi: 10.1016/j.chroma.2012.12.041. Epub 2012 Dec 26. PubMed PMID: 23347976; PubMed Central PMCID: PMC3581436.

Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek WM, Wang K, Ludewig G, Robertson LW. Does Dietary Copper Supplementation Enhance or Diminish PCB126 Toxicity in the Rodent Liver? Chem Res Toxicol. 2013 Apr 15. PMID: 23527585, PMCID:PMC3660509

Lehmler, H.-J. , X. He, M.W. Duffel, S. Parkin, 3,4’,5-Trichlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. C 2013: E69, o620. PMID:23634142, PMCID:PMC3629655

Lehmler, H.J., He, X., Li, X., Duffel, M.W., and Parkin, S. 2013. Effective Synthesis of Sulfate Metabolites of Chlorinated Phenols. Chemosphere, 93:1965-1971. PMID: 23906814, PMCID:PMC3815985

Lehmler,H.-J., H. Wu, S. Parkin, 5,5’-Dichloro-2,2’-dimethoxybiphenyl. Acta Cryst. C 2013: E69, o650. PMCID: PMC3647848.

Lehmler, H.-J. , H. Wu, S. Parkin, 2,2’,5’,6-Tetrachloro-4-[(1S)-1-methylpropoxy]biphenyl. Acta Cryst. C 2013: E69, 0983. PMCID: PMC3685116.

Marek, R. F., Martinez, A., Hornbuckle, K. C., Discovery of hydroxylated polychlorinated biphenyls (OH-PCBs) in sediment from a lake Michigan waterway and original commercial aroclors, July 17, 2013 Environmental Science & Technology. PMID:23862721 PMCID: Journal in-process.

Marek, R. F., Thorne, P. S., Wang, K., DeWall, J., Hornbuckle, K. C. (2013). PCBs and OH-PCBs in Serum from Children and Mothers in Urban and Rural U.S. Communities. Environmental Science & Technology, 47(7), 3353–3361. PMID 23452180, PMCID: PMC3645264.

Meggo, RE; Schnoor, JL (2013). Cleaning polychlorinated biphenyl (PCB) contaminated garden soil by phytoremediation. Environmental Sciences, 1, 33 – 52. PMID:24409084, PMCID: PMC3883314

Meggo, RE; Schnoor, JL; Hu, D. (2013). Dechlorination of PCBs in the rhizosphere of switchgrass and poplar, Environmental Pollution, 178, 312–321. PMID:23603468, PMCID: PMC4294558

Meggo, RE; Schnoor, JL (2013). Rhizosphere redox cycling and implications for rhizosphere biotransformation of selected polychlorinated biphenyl congeners. Ecological Engineering, 57, 285–292, PMID:24860241, PMCID: PMC4028954

Petrich, N. T., Spak, S. N., Carmichael, G. R., Hu, D., Martinez, A., Hornbuckle, K. C. (In Press) Simulating and explaining passive air sampling rates for semi-volatile compounds on polyurethane foam passive samplers. July 25, 2013 Environmental Science & Technology. PMID 23837599, PMCID:PMC3764502.

Qin, X., Lehmler, H-J., Teesch, L.M., Robertson, L.W., and Duffel, M.W. 2013 “Chlorinated Biphenyl Quinones and Phenyl-2,5-benzoquinone Differentially Modify the Catalytic Activity of Human Hydroxysteroid Sulfotransferase hSULT2A1.” Chemical Research in Toxicology, 26:1474-85. PMID:24059442, PMCID: PMC3846294.

Qin, X., Teesch, L.M. and Duffel, M.W. 2013. “Modification of the Catalytic Function of Human Hydroxysteroid Sulfotransferase hSULT2A1 by Formation of Disulfide Bonds.” Drug Metabolism and Disposition, 41:1094-1103. PMID:23444386, PMCID: PMC3629806

Rignall, B, K. Grote, A. Gavrilova, M. Weimer, A. Kopp-Schneider, E. Krause, K.E. Appel, A. Buchmann, L.W. Robertson, H.-J. Lehmler, I. Kania-Korwel, I. Chahoud, M. Schwarz, Biological and tumor promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol. Sci. 2013: 133: 29-41. PMID:23457121, PMCID: PMC3627557.

Salman KN, Stuart MA, Schmidt J, Borges T, McClain CJ, Robinson FR, Li M, Robertson LW. The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int. 2013 Mar 28. [Epub ahead of print]PMID: 23532536, PMCID: PMC3732555.

Shen H, Li M, Wang B, Lai IK, Robertson LW, Ludewig G. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Environ Sci Pollut Res Int. 2013 May 4. [Epub ahead of print] PubMed PMID: 23644946, PMCID: PMC3769429

Tehrani R, Van Aken B. Hydroxylated polychlorinated biphenyls in the environment: sources, fate, and toxicities. Environ Sci Pollut Res Int. 2013 May 2. PubMed PMID: 23636595.PMCID:PMC3812322

Wu, X., Kania-Korwel, I., Chen, H., Stamou, M., Dammanahalli, K.J., Duffel, M., Lein P.J., and Lehmler, H.-J. 2013. “Metabolism of 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) Atropisomers in Tissue Slices from Phenobarbital or Dexamethasone-Induced Rats is Sex-Dependent.” Xenobiotica, 43:933-947; PMID 23581876,PMCID: PMC3878182

Yucuis, R. A., Stanier, C. O., Hornbuckle, K. C. (2013). Cyclic Siloxanes in Air, Including Identification of High Levels in Chicago and Distinct Diurnal Variation. August, 2013 Chemosphere, 92(8), 905–910. PMID 23541357 PMCID:PMC3975597

Zhai, GS; Lehmler, HJ; Schnoor, JL (2013). Sulfate metabolites of 4-monochlorobiphenyl in whole poplar plants. Environ. Sci. Technol. 47, 557−562, doi: 10.1021/es303807f; PMID: 23215248, PMCID:PMC3565590.

Zhai, GS; Lehmler, HJ; Schnoor, JL (2013). Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar. Environ. Sci. Technol. 47, 6829−6835, dx.doi.org/10.1021/es304298m; PMID: 23320482 PMCID: PMC3652898.

Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Identification of hydroxylated metabolites of 3,3′,4,4′-tetrachlorobiphenyl and metabolic pathway in whole poplar plants, Chemosphere 81, 523-528, DOI: 0.1016/j.chemosphere.2010.07.036, PMID: 20708213, PMCID:PMC2943055.

Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Hydroxylated Metabolites of 4-Monochlorobiphenyl and Its Metabolic Pathway in Whole Poplar Plants, Environ. Sci. Technol. 44, 3901-3907, DOI: 10.1021/es100230m, PMID: 20402517, PMCID: PMC2891041.

2012

Ambati J, Song Y, Rankin SE, Lehmler HJ. Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation. J Phys Chem A. 2012 Feb 16;116(6):1586-95. PMID: 22257259; PubMed Central PMCID: PMC3417754.

Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene. 2012 Mar 8;31(10):1207-16. PMID: 21804600; PubMed Central PMCID: PMC3208126.

Dhakal K, He X, Lehmler HJ, Teesch LM, Duffel MW, Robertson LW. Identification of Sulfated Metabolites of 4-Chlorobiphenyl (PCB3) in the Serum and Urine of Male Rats. Chem Res Toxicol. 2012 Dec 17;25(12):2796-804. PMID: 23137097; PubMed Central PMCID: PMC3524396.

Hu, X., Adamcakova-Dodd, A., Lehmler, H.-J., Hu, D., Hornbuckle, K. C., Thorne, P. S. (2012). Subchronic Inhalation Exposure Study Of An Airborne Polychlorinated Biphenyl Mixture Resembling The Chicago Ambient Air Congener Profile. Environmental Science & Technology, 46(17), 9653-9662. PMID: 22846166 PMCID: PMC3573703

Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16;46(20):11393-401. PMID: 22974126; PubMed Central PMCID: PMC3475189.

Kania-Korwel I, Lehmler HJ. Assigning atropisomer elution orders using atropisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism. J Chromatogr A. 2013 Feb 22;1278:133-44. doi: 10.1016/j.chroma.2012.12.041. Epub 2012 Dec 26. PubMed PMID: 23347976; PubMed Central PMCID: PMC3581436.

Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16;46(20):11393-401. doi: 10.1021/es302810t. Epub 2012 Sep 28. PubMed PMID: 22974126; PubMed Central PMCID: PMC3475189.

Ludewig G, Robertson LW. Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma. Cancer Lett. 2012 Dec 2. doi:pii: S0304-3835(12)00703-3. 10.1016/j.canlet.2012.11.041. PMID: 23211541.,PMCID:PMC3648605

Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology. 2012 Dec 8;302(1):25-33. PubMed PMID: 22824115; PubMed Central PMCID: PMC3438370.

Marek, R. F., Thorne, P. S., Wang, K., DeWall, J., Hornbuckle, K. C. (In Press) PCBs and OH-PCBs in Serum from Children and Mothers in Urban and Rural U.S. Communities. Environmental Science & Technology. PMID:23452180 PMCID: PMC 3645264

Martinez, A., Erdman, N. R., Rodenburg, Z. L., Eastling, P. M., Hornbuckle, K. C. (2012). Spatial distribution of chlordanes and PCB congeners in soil in Cedar Rapids, Iowa, USA. Environmental Pollution, 161, 222-228. PMID: 22230089 PMCID: PMC3255082.

Oldham ED, Xie W, Farnoud AM, Fiegel J, Lehmler HJ. Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutane sulfonate. J Phys Chem B. 2012 Aug 23;116(33):9999-10007. PubMed PMID: 22834732; PubMed Central PMCID: PMC3464004.

Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC. Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer Res. 2012 Aug 1;72(15):3807-16. PMID: 22710435; PubMed Central PMCID: PMC3429130.

Senthilkumar PK, Robertson LW, Ludewig G. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol. 2012 Feb 15;259(1):115-23. PubMed PMID: 22210444; PMCID: PMC3288560.

Shen H, Robertson LW, Ludewig G. Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats. Toxicol Lett. 2012 Mar 25;209(3):291-8. PubMed PMID: 22266287; PMCID: PMC3288253.

Tehrani R, Lyv MM, Kaveh R, Schnoor JL, Van Aken B. Biodegradation of mono-hydroxylated PCBs by Burkholderia xenovorans. Biotechnol Lett. 2012 Dec;34(12):2247-52. doi: 10.1007/s10529-012-1037-x. Epub 2012 Aug 24. PubMed PMID: 22918793; PMCID: PMC3592572.

Yucius, R. A., Stanier, C. O., Hornbuckle, K. C. (In Press) Cyclic Siloxanes in Air, Including Identification of High Levels in Chicago and Distinct Diurnal Variation. Chemosphere.PMID:23541357, PMCID:PMC3975597

2011

Buettner GR. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem. 2011 May 1; 11 (4) :341-6. PubMed Central PMCID: PMC3131414.

Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene. 2011 Aug 1; PubMed PMID:21804600; PubMed Central PMCID: PMC3208126 [Available on 2013/2/1].

Ekuase EJ, Liu Y, Lehmler HJ, Robertson LW, Duffel MW. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol. 2011 Oct 17; 24 (10) :1720-8. PMID:21913674; PMCID: PMC3196794 [Available on 2012/10/17].

Gulcan HO, Duffel MW. Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes. Arch Biochem Biophys. 2011 Mar 15; 507 (2) :232-40. PubMed PMID:21187059; PubMed Central PMCID: PMC3058861 [Available on 2012/3/15].

Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler HJ. Synthesis of Sterically Hindered Polychlorinated Biphenyl Derivatives. Synthesis (Stuttg). 2011 Jan 1;7:1045-1054. PMID: 21516177; PMCID: PMC3080045 [Available on 2012/1/1]

Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler HJ. Regioselective Iodination of Chlorinated Aromatic Compounds Using Silver Salts. Tetrahedron. 2011 Sep 30; 67 (39) :7461-7469. PubMed PMID:21918585; PubMed Central PMCID: PMC3170769 [Available on 2012/9/30].

Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague Dawley rats. Toxicol Sci. 2011 Aug 24. [Epub ahead of print] PubMed PMID: 21865291.

Liu Y, Lehmler HJ, Robertson LW, Duffel MW. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact. 2011 Feb 1;189(3):153-60. Epub 2010 Dec 3. PMID: 21130751; PMCID: PMC3032042 [Available on 2012/2/1]

Martinez A, Hornbuckle KC. Record of PCB congeners, sorbents and potential toxicity in core samples in Indiana Harbor and Ship Canal. Chemosphere. 2011 Oct; 85 (3) :542-7. PubMed PMID:21899876; PubMed Central PMCID: PMC3222236 [Available on 2012/10/1].

Robertson LW, Ludewig G. Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrst Reinhalt Luft. 2011 Jan;71(1-2):25-32. PMCID: PMC3113507.

Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett. 2011 Jul 4;204(1):64-70. Epub 2011 Apr 21. PubMed PMID: 21530622; PMCID: PMC3109099.

Song Y, Ambati J, Parkin S, Rankin SE, Robertson LW, Lehmler HJ. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere. 2011 Aug 6. [Epub ahead of print] PubMed PMID: 21824639.

Wagner BA, Venkataraman S, Buettner GR. The rate of oxygen utilization by cells. Free Radic Biol Med. 2011 Aug 1; 51 (3) :700-12. PubMed PMID:21664270; PubMed Central PMCID: PMC3147247 [Available on 2012/8/1].

Zhai G, Hu D, Lehmler HJ, Schnoor JL. Enantioselective biotransformation of chiral PCBs in whole poplar plants. Environ Sci Technol. 2011 Mar 15;45(6):2308-16. Epub 2011 Feb 17. PMID: 21329345; PMCID: PMC3066656 [Available on 2012/3/15]

2010
  • Aken BV, Correa PA, Schnoor JL. Phytoremediation of polychlorinated biphenyls: new trends and promises. Environ Sci Technol. 2010 Apr 15; 44 (8) :2767-76. PMCID: PMC3025541.
  • Chan, K., H.-J. Lehmler, M. Sivagnanam, C. Yan Feng, L. W. Robertson, P. J. O’Brien. Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes. J. Appl. Toxicol. 2010 Mar;30(2):163-71. PMID: 19830680.
  • Correa P.A.; L. Lin; C.L. Just; D. Hu; K.C. Hornbuckle; J.L .Schnoor; B. Van Aken. The Effects of Individual PCB Congeners on the Soil Bacterial Community Structure and the Abundance of Biphenyl Dioxygenase Genes. Environ Intl. 2010 Nov; 36(8):901-6. epub 2009 Aug 28.. PMID: 19716603.
  • Duffel, M.W. Sulfotransferases. In: Biotransformation: Volume 4 of Comprehensive Toxicology (F.P. Guengerich, ed.). Elsevier, Oxford, (accepted March, 2008). In Press. 2010.
  • Flor S, Ludewig G. Polyploidy-induction by dihydroxylated monochlorobiphenyls: structure-activity-relationships. Environ Int. 2010 Nov; 36 (8) :962-9. PMCID: PMC2949501.
  • Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G. 3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ Int. 2010 Nov; 36 (8) :970-9. PMCID: PMC2949545.
  • Kania-Korwel, I., M.H.M.E. El-Komy, P. Veng-Pedersen, H.-J. Lehmler (2010). Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57Bl/6 mice. Environ. Sci. Technol. 2010 Apr 15;44(8):2828-35. PMCID: PMC2855138.
  • Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int. 2010 Nov; 36 (8) :918-23. PMCID: PMC2891598.
  • Lehmler, H-J, S. J. Harrad, H. Hühnerfuss, I. Kania-Korwel, C. M. Lee, Z. Lu, C. S. Wong (2010). Chiral polychlorinated biphenyl transport, metabolism and distribution – A review. Environ. Sci. Technol. 2010 Apr 15;44(8):2757-66. PMCID: PMC2855137
  • Lehmler HJ, Telu S, Vyas SM, Shaikh NS, Rankin SE, Knutson BL, Parkin S. Synthesis and Solid State Structure of Fluorous Probe Molecules for Fluorous Separation Applications. Tetrahedron. 2010 Apr 3; 66 (14) :2561-2569. PMCID: PMC2840617.
  • Li X., S. Parkin, M.W. Duffel, L.W. Robertson and H.-J Lehmler. 3',4'-Dichlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. (2010). E66, o1615–o1616. Open Access PDF
  • Li, X., S. Parkin, M. W. Duffel, L. W. Robertson, H.-J. Lehmler (2009). An efficient approach to sulfate metabolites of polychlorinated biphenyls. Environ. Intl. 2010 Nov;36(8):843-8. Epub 2009 Apr 5. PMID: 19345419.
  • Li X., S. Parkin, M.W. Duffel, L.W. Robertson, H.-J. Lehmler, Biphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. E 2010: 66, o1073. Open Access PDF
  • Martinez A. , K. Norström, K. Wang, K.C. Hornbuckle. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan. Environ. Intl, 2010 Nov;36(8):849-54. Epub 2009 Mar 5. PMCID: PMC2888873.
  • Milanowski B, Lulek J, Lehmler HJ, Kania-Korwel I. Assessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses. Environ Int. 2010 Nov; 36 (8) :884-92. PMCID: PMC2891895.
  • Norström K.; G. Czub; M.S. McLachlan; D. Hu; P.S. Thorne; K.C. Hornbuckle. External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment. Environ Intl, 2010 Nov;36(8):855-61. Epub 2009 Apr 24. PMCID: PMC2891214
  • Persoon, C., T. M. Peters, K. Kumar, K. C. Hornbuckle. Spatial distribution of airborne polychlorinated biphenyls in Cleveland, Ohio and Chicago, Illinois. Environ. Sci. Technol., 2010 Apr 15;44(8):2797-802. PMCID: PMC2855146.
  • Song Y, Buettner GR. Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide. Free Radic Biol Med. 2010 Sep 15; 49 (6) :919-62. PMCID: PMC2936108.
  • Song Y., S. Parkin, H.-J. Lehmler. 1-Bromo-2,3,6-trichloro-4,5-dimethoxy-benzene. Acta Cryst. E 2010: E66, o487. Open Access PDF
  • Song Y., S. Parkin, H.-J. Lehmler, 1-Bromo-4-chloro-2,5-dimethoxybenzene. Acta Cryst. E 2010: E66, o339. Open Access PDF
  • Telu S, Parkin S, Robertson LW, Lehmler HJ. Improved syntheses of non-dioxin-like polychlorinated biphenyls (PCBs) and some of their sulfur-containing metabolites. Environ Int. 2010 Nov; 36 (8) :828-34. PMCID: PMC2948577.
  • Xie W, Bothun GD, Lehmler HJ. Partitioning of perfluorooctanoate into phosphatidylcholine bilayers is chain length-independent. Chem Phys Lipids. 2010 Mar; 163 (3) :300-8. PMCID: PMC2841784.
  • Xie W, Ludewig G, Wang K, Lehmler HJ. Model and cell membrane partitioning of perfluorooctanesulfonate is independent of the lipid chain length. Colloids Surf B Biointerfaces. 2010 Mar 1; 76 (1) :128-36. PMCID: PMC2818369.
  • Xie W, Wang K, Robertson LW, Ludewig G. Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites. Environ Int. 2010 Nov; 36 (8) :950-61. PMCID: PMC2888624.
  • Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Identification of hydroxylated metabolites of 3,3′,4,4′-tetrachlorobiphenyl and metabolic pathway in whole poplar plants, Chemosphere 81, 523-528, DOI: 10.1016/j.chemosphere.2010.07.036, PMID: 20708213, PMCID:PMC2943055.
  • Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Hydroxylated Metabolites of 4-Monochlorobiphenyl and Its Metabolic Pathway in Whole Poplar Plants, Environ. Sci. Technol. 44, 3901-3907, DOI: 10.1021/es100230m, PMID: 20402517, PMCID: PMC2891041.
  • Zhao H., A. Adamcakova-Dodd, D. Hu, K.C. Hornbuckle, C.L. Just, L.W. Robertson, P.S. Thorne, H.-J. Lehmler. Development of a Synthetic PCB Mixture Resembling the Average Polychlorinated Biphenyl Profile in Chicago Air. Environ Intl 2010 Nov;36(8):819-27. PMCID: PMC2888912.
2009
  • Dreiem A., S. Rykken, H.-J. Lehmler, L. W. Robertson, F. Fonnum. Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells. Toxicol. Appl. Pharmacol. 2009 Oct 15;240(2):306-13. PMCID: PMC2753730
  • Kloesener J, T. Peters, A. Dodd, L. Teesch, P.S. Thorne, L.W. Robertson, G. Luthe. Innovative application of fluoro-tagging to trace airborne particulate and gas phase PBDE exposures. Chem. Res. Toxicol. 2009 Jan;22(1):179-86. PMID: 19111055
  • Li, X., L. W. Robertson, H.-J. Lehmler. Electron ionization mass spectral fragmentation study of sulfation derivatives of polychlorinated biphenyls. Chem. Cent. J. 3: 5. 2009. PMCID: PMC2660904
  • Liu Y., J. Smart, Y. Song, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. 2009. Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status. Drug Metabol. and Disposi, 2009 May; 37(5): 1065–1072. Epub 2009 Feb 5. PMCID: PMC2677757
  • Persoon C., K. C. Hornbuckle. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere 2009. 74(7), 917-923. PMCID: PMC2657292
  • Pessah I.N., H.-J. Lehmler, L.W. Robertson, C.F. Perez, E. Cabrales, D. Bose, W. Feng. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem. Res. Toxicol. 2009 Jan;22(1):201-7. PMCID: PMC2662366
  • Ptak, A., G. Ludewig, A. Rak, W. Nadolna, M. Bochenek, E. L. Gregoraszczuk. Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxlylated metabolites on cellular apoptosis. Environ Intl. 2009 Jul 13. [Epub ahead of print]. PMID: 19604582 PMCID: PMC2904404 [Available on 2011/11/1]
  • Song Y., B. A. Wagner, J. R. Witmer, H.-J. Lehmler, G. R. Buettner. Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc. Natl. Acad. Sci. USA. 2009; 106:9725–9730. PMCID: PMC2689812
  • Spencer, W. A., H. J. Lehmler, L. W. Robertson, R. C. Gupta. Oxidative DNA adducts following Cu2+-mediated activation of dihydroxy PCBs: Role of reactive oxygen species. Free Radic. Biol. Med. 2009; 46(10): 1346-1352. PMCID: PMC2744390
  • Suh Y.-W., G. R. Buettner, S. Venkataraman, S. E. Treimer, L. W. Robertson, G. Ludewig. UVA/B-induced formation of free radicals from 2-decabromodiphenyl ether (deca-BDE). Environ. Sci. Technol. 2009; 43(7):2581-2588. PMCID: PMC2685467
  • Wangpradit O., S. Mariappan, L. Teesch, K. Norstrom, M. Duffel, L.W. Robertson, G. Luthe. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem. Res. Toxicol. 2009 Jan: 22(1):64-71. PMCID: PMC2637223
  • Wombacher W.D. and K.C. Hornbuckle. Synthetic Musk Fragrances in a Conventional Drinking Water Treatment Plant with Lime Softening.SCE J Environ. Engin. 2009, 135(11): 1192-1198. http://dx.doi.org/10.1061/(ASCE)EE.1943-7870.0000085.
  • Xie, W., Q. Wu, I. Kania-Korwel, J. C. Tharappel, S. Telu, M. C. Coleman, H.P. Glauert, K. Kannan, S.V. Santhana Mariappan, D.R. Spitz, J. Weydert, H.-J. Lehmler. Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats. Arch. Toxicol 2009 Oct;83(10):909-24. PMCID: PMC2755535
2008
  • Glauert H.P., J.C. Tharappel, S. Banerjee, N. L.S. Chan, I. Kania-Korwel, H.-J. Lehmler, E.Y. Lee, L.W. Robertson, B.T. Spear. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappaB in mice. Toxicol. Appl. Pharmacol. 232, 302-308 (2008). PMCID: PMC2583134
  • Glauert H.P., J.C. Tharappel, Z. Lu, D. Stemm, S. Banerjee, L.S. Chan, E.Y. Lee, H.-J. Lehmler, L.W. Robertson and B.T. Spear, Role of oxidative stress in the promoting activities of PCBs. Environ. Toxicol. Pharmacol. 25, 247-250 (2008). PMID: 19122744.
  • Gregoraszczuk E.L., A. Rak, G. Ludewig and A. Gasin´ska. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environ. Toxicol. Pharmacol. 2008; 25(2): 227-233. Abstract
  • Gulcan H.O., L. Yungang and M.W. Duffel. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chemical Research in Toxicology, 21:1503-8. PMCID: PMC2548291
  • Hu, D.; Martinez, A.; Hornbuckle, K.C. Discovery of non-aroclor PCB (3,3′-Dichlorobiphenyl) in Chicago air. Environ. Sci. Technol.; 2008; 42(21); 7873-7877. PMCID: PMC2646757
  • Jacobus J.A., S. Flor, A.J. Klingelhutz, L.W. Robertson and G. Ludewig, 2-(4-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres. Environ. Toxicol. Pharmacol. 2008; 25, 267-272. PMCID: PMC2346440
  • Kania-Korwel I., K.C. Hornbuckle, L.W. Robertson, and H.-J. Lehmler. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food and Chemical Toxicology 46, 637–644 (2008). PMCID: PMC2289907
  • Kania-Korwel I., K. Hornbuckle, L. Robertson, H.-J. Lehmler. Dose-Dependent Enantiomeric Enrichment of 2,2',3,3',6,6'-Hexachlorobiphenyl in Female Mice. Environ Toxicol Chem. 27, 299-305 (2008). PMID: 18348647
  • Kania-Korwel I., S.M. Vyas, Y. Song, H.-J. Lehmler. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J. Chromatogr. A 2008:1207, 146-154. PMCID: PMC2579784
  • Kania-Korwel I., W. Xie, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantiomeric enrichment of 2,2’,3,3’,6,6’-hexachlorobiphenyl (PCB 136) in mice after induction of CYP enzymes. Arch. Environ. Contam. Toxicol. 2008: 55, 510-517. PMID: 18437444
  • Kania-Korwel I , E.G. Hrycay, S.M. Bandiera, H.-J. Lehmler. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem. Res. Toxicol. Vol 21 (6), 1295-1303, 2008. PMCID: PMC2574739
  • Kania-Korwel I., H. Zhao, K. Norstrom, X. Li, K.C. Hornbuckle, H.-J. Lehmler, Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J. Chromatogr. A 2008 Dec 19;1214(1-2):37-46. Epub 2008 Oct 31. PMCID: PMC2648864
  • Klösener J., D. C. Swenson, L. W. Robertson and G. Luthe. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Cryst. B64, 108–119 (2008). PMID: 18204217
  • Lehmler H.J., L. Xu, S.M. Vyas, V.A. Ojogun B.L. Knutson and G. Ludewig. Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle. Journal of Pharmaceutics, Vol 353 (1-2), 35-44, 2008. PMCID: PMC2408535
  • Li X., S. Parkin, L. W. Robertson, H.-J. Lehmler. 4’-Chlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. E64, o2464 (2008). Open Access PDF
  • Liu J., J. L. Schnoor. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere, 73(10), November 2008: 1608-1616. PMCID: PMC2668963
  • Ludewig G., L. Lehmann, H. Esch and L.W. Robertson. Metabolic activation of PCBs to carcinogens in vivo—A review. Environ. Toxicol. Pharmacol. 2008; 25, 241-246. PMCID: PMC2364599
  • Luthe G., R. Boy, J. Jacobus, B. Smith, A. Rahaman, L. W. Robertson, G. Ludewig. Xenobiotic Geometry and Media pH determine Cytotoxicity through Solubility. Chem. Res. Toxicol. Vol 21 (5), 1017-1027, 2008. PMID: 18402468
  • Luthe G., J.A. Jacobus and L.W. Robertson. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment. Environ. Toxicol. Pharmacol. 2008; 25, 202-210. PMCID: PMC2746664
  • Maddox C., B. Wang, P.A. Kirby, K. Wang, and G. Ludewig. Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats. Environ. Toxicol. Pharmacol. 2008; 25(2), 260-266. PMCID: PMC2346436
  • Persoon C., K.C. Hornbuckle. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere. 2009 Feb;74(7):917-23. Epub 2008 Dec 9. PMCID: PMC2657292
  • Ptak, A., G. Ludewig, E. L. Gregoraszczuk. A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J. Physiol. Pharmacol. 2008: 59(3), 577-588. PMID: 18953099
  • Ravoori S., P. Ayotte, C. Srinivasan, D. Pereg, L.W. Robertson, G.K. Russell, J. Jeyabalan and R.C. Gupta. DNA damage associated with PCBs in the whole blood cells of Inuit. Environmental Toxicology and Pharmacology 25, 273-276 (2008). Abstract
  • Robertson L.W., W. Sulkowski and B. Hennig, Preface. Special Issue of ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, FOCUS ON PCBs: RECENT ADVANCES IN ENVIRONMENTAL DISTRIBUTION AND HEALTH EFFECTS, Guest Editors: Larry Robertson, Wieslaw Sulkowski and Bernhard Hennig, Vol. 25, issue 2 March 2008, 127.
  • Sacco J.C., H.-J. Lehmler, L.W. Robertson, W. Li, and M.O. James. Glucuronidation of polychlorinated biphenylols and UDPGA concentration in channel catfish liver and intestine. Drug Metabolism and Disposition 36, 623–630 (2008). PMID: 18180271
  • Shaikh N.S. , S. Parkin, G. Luthe, H.-J. Lehmler. The three-dimensional structure of 3,3′,4,4′-tetrachlorobiphenyl, a dioxin-like polychlorinated biphenyl (PCB), Chemosphere. 2008 February; 70(9): 1694–1698. PMCID: PMC2430941
  • Song Y., G. Buettner, S. Parkin, B. Wagner, L.W. Robertson, H.-J. Lehmler. Chlorination Increases the Persistence of Semiquinone Free Radicals Derived from Polychlorinated Biphenyl Hydroquinones and Quinones. Journal of Organic Chemistry 73, 8296-8304 (2008). PMCID: PMC2629131
  • Song Y., B.A. Wagner, H.-J. Lehmler, G.R. Buettner. Semiquinone radicals from oxygenated polychlorinated biphenyls: Electron paramagnetic resonance studies. Chem. Res. Toxicol. 2008; 21(7), 1359-1367. PMCID: PMC2740386
  • Stemm D.N., J.C. Tharappel, H.-J Lehmler, C. Srinivasan, J. S. Morris, V.L. Spate, L.W. Robertson, B.T. Spear and H.P. Glauert. Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3’,4,4’-Tetrachlorobiphenyl and 2,2’,4,4’,5,5’-Hexachlorobiphenyl. Exp. Biol. Med. 233, 366–376 (2008). PMID: 18296742
  • Telu S., S. Parkin, L.W. Robertson, H.-J. Lehmler, 1,3,5-Trichloro-2-methoxybenzene. Acta Cryst. E 2008: 64, o424. Full-text PDF
  • Tharappel J.C., H.-J. Lehmler, C. Srinivasan, L.W. Robertson, B.T. Spear, H.P. Glauert. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3’,4,4’-tetrachlorobiphenyl (PCB-77). Food Chem. Toxicol. 2008; 46, 3467-3474. PMCID: PMC2597727
  • Venkatesha V.A., S. Venkataraman, E.H. Sarsour, A.L. Kalen, G.R. Buettner, L.W. Robertson, H.-J. Lehmler, P.C. Goswami. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in non-malignant human breast epithelial cells. Free Radic. Biol. Med. 2008: 45, 1094-1102. PMCID: PMC2614346
2007
  • Bunaciu R.P., J.C. Tharappel, H.-J. Lehmler, I. Korwel, L.W. Robertson, C. Srinivasan, B.T. Spear, and H.P. Glauert. The Effect of Dietary Glycine on the Hepatic Tumor Promoting Activity of Polychlorinated Biphenyls (PCBs) in Rats. Toxicology 239, 147–155 (2007). PMCID: PMC2063585
  • Kania-Korwel I., N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-Hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 2007: 19, 56-66. PMID: 17089340
  • Lehmann L., H.L. Esch, P.A. Kirby, L.W. Robertson, G. Ludewig. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478, 2007. PMID: 16950798
  • Ludewig G., H. Esch, L.W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094, 2007.
  • Luthe G., D. C. Swenson and L.W. Robertson. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3), Acta Crystallographica, Section B: Structural Science 63, 319-327 (2007). PMID: 17374943
  • Robertson L. W., I. Berberian, T. Borges, L. Chen, C.K. Chow, H.P. Glauert, J.G. Filser and H. Thomas. Suppression of peroxisomal enzyme activities and cytochrome P-4504A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR Research, vol. 2007, Article ID 15481, 5 pages, 2007. PMCID: PMC2220027
  • Sadeghi-aliabadi H., K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem.-Biol. Interactions 2007: 167, 184-192. PMID: 17408604
  • Song Y., S. Parkin, H.-J. Lehmler. 4-Bromo-2-chloro-1-methoxybenzene. Acta Cryst. E 2007: 63, o2091-o2092.
  • Strathmann, J., K. Paal, C. Ittrich, E. Krause, K. E. Appel, H. P. Glauert, A. Buchmann, M. Schwarz. Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics 2007; 7(18): 3318-3331. PMID: 17722141.
  • Zettner M.A., S. Flor, G. Ludewig, J. Wagner, L.W. Robertson, L. Lehmann. Quinoid Metabolites of 4-monochlorobiphenyl (PCB3) Induce Gene Mutations in Cultured Chinese Hamster V79 Cells. Toxicological Sciences 100, 88–98 (2007). PMID: 17686921
2006
  • Bender R.P., H.-J. Lehmler, L.W. Robertson, G. Ludewig, N. Osheroff. Polychlorinated Biphenyl Quinone Metabolites Poison Human Topoisomerase IIalpha: Altering Enzyme Function by Blocking the N-Terminal Protein Gate. Biochemistry. PMID: 16906772
  • Gooding, M.P., T.J. Newton, M.R. Bartsch, K.C. Hornbuckle. Toxicity of synthetic musks to early life stages of the freshwater mussel Lampsilis cardium. Arch. Environ. Contam. Toxicol. 51(4): 549-558 (2006). PMID: 16944041. PMCID: PMC2757453
  • Hornbuckle, K. C., D. L. Carlson, D. L. Swackhamer, J. E. Baker, S. J. Eisenreich. Polychlorinated Biphenyls in the Great Lakes. In The Handbook in Environmental Chemistry/Water Pollution. R. A. Hites. Heidelberg, Springer-Verlag: 13-70 (2006).
  • Kania-Korwel I., A.W. Garrison, J.K. Avants, K.C. Hornbuckle, L.W. Robertson, W.W. Sulkowski, H.-J. Lehmler, Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat. Environmental Science & Technology 40, 3704-3710 (2006). Open Access PDF
  • Kunz S., H.-J. Schmitz, A. Buchmann, M. Schwarz, B. Schilling, O. Päpke, H.-J. Lehmler, L.W. Robertson and D. Schrenk. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicology Letters 164, 133–143 (2006). PMID: 16426774
  • Liu Y., T.I. Apak, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem. Res. Toxicol. 2006: 19, 1420-1425. PMID: 17112228
  • Luthe G., P.E.G. Leonards, G.S. Reijerink, H. Liu, J.E. Johansen, L.W. Robertson, Monofluorinated analogues of polybrominated diphenyl ethers (F-PBDEs) as analytical standards: Synthesis, NMR and GC-MS characterization and molecular orbital studies. Environ Sci Technol 2006: 40, 3023-3029. PMID: 16719106
  • Peck, A.M., K.C. Hornbuckle. Environmental sources, occurrence, and effects of synthetic musk fragrances. J. Environ. Monit. 2006: 8(9), 874-879.
  • Peck, A. M., K. C. Hornbuckle. Synthetic musk fragrances in urban and rural air of North America. Atmos. Environ. 2006: 40(32), 6101-6111.
  • Peck, A. M., E. Linebaugh, K. C. Hornbuckle. Synthetic musk fragrances in Lake Erie and Lake Ontario sediment cores. Environ. Sci. Technol. 2006: 40(16), 5629-5635. PMCID: PMC2757450
  • Ptak A., G. Ludewig, M. Kapiszewska, Z. Magnowska, H.J. Lehmler, L.W. Robertson, E.L. Gregoraszczuk. Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicology Letters 166, 200-211, 2006. PMID: 16949219
  • Ptak A., G. Ludewig, L.W. Robertson, H.-J. Lehmler and E.L. Gregoraszczuk. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters 164, 113–122 (2006). PMID: 16412591
  • Shaikh, N. S., S. Parkin, H.-J. Lehmler. 2,2',3,3',6,6'-Hexachloro-5-nitro-1,1'-biphenyl (5-Nitro PCB 136). Acta Cryst. E 2006: E62(2), o662-o663.
  • Shaikh N.S., D.C. Swenson, H.-J. Lehmler. 2,3,6-Trichloroiodobenzene. Acta Cryst. E 2006: 62, o4672-o4673.
  • Strathmann J., M. Schwarz, J.C. Tharappel, H. P. Glauert, B.T. Spear, L.W. Robertson, K.E. Appel, A. Buchmann. PCB 153, a non-dioxin-like tumor promoter, selects for ß-Catenin (Catnb) mutated mouse liver tumors. Toxicol. Sci. PMID: 16782779
  • Vyas, S. M., S. Parkin, H.-J. Lehmler. 2,2',3,4,4',5,5'-Heptachlorobiphenyl (PCB 180). Acta Cryst. E 2006; E62(7): o2905-o2906.
  • Vyas S.M., S. Parkin, L.W. Robertson, H.-J. Lehmler. 2,5-Dichloro-4'-methoxybiphenyl. Acta Cryst. E 2006: 62, o4162–o4163. Full-text PDF (with permission from publisher)
  • Vyas S.M., S. Parkin, L.W. Robertson, H-J. Lehmler. 4 -Chloro-2’,3’-dimethoxybiphenyl. Acta Crystallographica Section E E62, o3639–o3640 (2006). Full-text PDF (with permission from publisher)
  • Wang L.-Q., H.-J. Lehmler, L.W. Robertson, and M.O. James. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem.-Biol. Interactions 159, 235-246 (2006). PMID: 16413005
  • Weldon, M B., K.C. Hornbuckle. Concentrated animal feeding operations, row crops and their relationship to nitrate in Eastern Iowa rivers. Environ. Sci. Technol. 2006; 40(10): 3168-3173. PMCID: PMC2745718.