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Publications

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2014

2013

2012

  • Ambati J, Song Y, Rankin SE, Lehmler HJ. Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation. J Phys Chem A. 2012 Feb 16;116(6):1586-95. PMID: 22257259; PubMed Central PMCID: PMC3417754.
  • Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene. 2012 Mar 8;31(10):1207-16. PMID: 21804600; PubMed Central PMCID: PMC3208126.
  • Dhakal K, He X, Lehmler HJ, Teesch LM, Duffel MW, Robertson LW. Identification of Sulfated Metabolites of 4-Chlorobiphenyl (PCB3) in the Serum and Urine of Male Rats. Chem Res Toxicol. 2012 Dec 17;25(12):2796-804. PMID: 23137097; PubMed Central PMCID: PMC3524396.
  • Hu, X., Adamcakova-Dodd, A., Lehmler, H.-J., Hu, D., Hornbuckle, K. C., Thorne, P. S. (2012). Subchronic Inhalation Exposure Study Of An Airborne Polychlorinated Biphenyl Mixture Resembling The Chicago Ambient Air Congener Profile. Environmental Science & Technology, 46(17), 9653-9662. PMID: 22846166 PMCID: PMC3573703
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16;46(20):11393-401. PMID: 22974126; PubMed Central PMCID: PMC3475189.
  • Kania-Korwel I, Lehmler HJ. Assigning atropisomer elution orders using atropisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism. J Chromatogr A. 2013 Feb 22;1278:133-44. doi: 10.1016/j.chroma.2012.12.041. Epub 2012 Dec 26. PubMed PMID: 23347976; PubMed Central PMCID: PMC3581436.
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16;46(20):11393-401. doi: 10.1021/es302810t. Epub 2012 Sep 28. PubMed PMID: 22974126; PubMed Central PMCID: PMC3475189.
  • Ludewig G, Robertson LW. Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma. Cancer Lett. 2012 Dec 2. doi:pii: S0304-3835(12)00703-3. 10.1016/j.canlet.2012.11.041. PMID: 23211541.,PMCID:PMC3648605
  • Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology. 2012 Dec 8;302(1):25-33. PubMed PMID: 22824115; PubMed Central PMCID: PMC3438370.
  • Marek, R. F., Thorne, P. S., Wang, K., DeWall, J., Hornbuckle, K. C. (In Press) PCBs and OH-PCBs in Serum from Children and Mothers in Urban and Rural U.S. Communities. Environmental Science & Technology. PMID:23452180 PMCID: PMC 3645264
  • Martinez, A., Erdman, N. R., Rodenburg, Z. L., Eastling, P. M., Hornbuckle, K. C. (2012). Spatial distribution of chlordanes and PCB congeners in soil in Cedar Rapids, Iowa, USA. Environmental Pollution, 161, 222-228. PMID: 22230089 PMCID: PMC3255082.
  • Oldham ED, Xie W, Farnoud AM, Fiegel J, Lehmler HJ. Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutane sulfonate. J Phys Chem B. 2012 Aug 23;116(33):9999-10007. PubMed PMID: 22834732; PubMed Central PMCID: PMC3464004.
  • Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC. Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer Res. 2012 Aug 1;72(15):3807-16. PMID: 22710435; PubMed Central PMCID: PMC3429130.
  • Senthilkumar PK, Robertson LW, Ludewig G. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol. 2012 Feb 15;259(1):115-23. PubMed PMID: 22210444; PMCID: PMC3288560.
  • Shen H, Robertson LW, Ludewig G. Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats. Toxicol Lett. 2012 Mar 25;209(3):291-8. PubMed PMID: 22266287; PMCID: PMC3288253.
  • Tehrani R, Lyv MM, Kaveh R, Schnoor JL, Van Aken B. Biodegradation of mono-hydroxylated PCBs by Burkholderia xenovorans. Biotechnol Lett. 2012 Dec;34(12):2247-52. doi: 10.1007/s10529-012-1037-x. Epub 2012 Aug 24. PubMed PMID: 22918793; PMCID: PMC3592572.
  • Yucius, R. A., Stanier, C. O., Hornbuckle, K. C. (In Press) Cyclic Siloxanes in Air, Including Identification of High Levels in Chicago and Distinct Diurnal Variation. Chemosphere.PMID:23541357, PMCID:PMC3975597

2011

  • Buettner GR. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem. 2011 May 1; 11 (4) :341-6. PubMed Central PMCID: PMC3131414.
  • Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene. 2011 Aug 1; PubMed PMID:21804600; PubMed Central PMCID: PMC3208126 [Available on 2013/2/1].
  • Ekuase EJ, Liu Y, Lehmler HJ, Robertson LW, Duffel MW. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol. 2011 Oct 17; 24 (10) :1720-8. PMID:21913674; PMCID: PMC3196794 [Available on 2012/10/17].
  • Gulcan HO, Duffel MW. Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes. Arch Biochem Biophys. 2011 Mar 15; 507 (2) :232-40. PubMed PMID:21187059; PubMed Central PMCID: PMC3058861 [Available on 2012/3/15].
  • Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler HJ. Synthesis of Sterically Hindered Polychlorinated Biphenyl Derivatives. Synthesis (Stuttg). 2011 Jan 1;7:1045-1054. PMID: 21516177; PMCID: PMC3080045 [Available on 2012/1/1]
  • Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler HJ. Regioselective Iodination of Chlorinated Aromatic Compounds Using Silver Salts. Tetrahedron. 2011 Sep 30; 67 (39) :7461-7469. PubMed PMID:21918585; PubMed Central PMCID: PMC3170769 [Available on 2012/9/30].
  • Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague Dawley rats. Toxicol Sci. 2011 Aug 24. [Epub ahead of print] PubMed PMID: 21865291.
  • Liu Y, Lehmler HJ, Robertson LW, Duffel MW. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact. 2011 Feb 1;189(3):153-60. Epub 2010 Dec 3. PMID: 21130751; PMCID: PMC3032042 [Available on 2012/2/1]
  • Martinez A, Hornbuckle KC. Record of PCB congeners, sorbents and potential toxicity in core samples in Indiana Harbor and Ship Canal. Chemosphere. 2011 Oct; 85 (3) :542-7. PubMed PMID:21899876; PubMed Central PMCID: PMC3222236 [Available on 2012/10/1].
  • Robertson LW, Ludewig G. Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrst Reinhalt Luft. 2011 Jan;71(1-2):25-32. PMCID: PMC3113507.
  • Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett. 2011 Jul 4;204(1):64-70. Epub 2011 Apr 21. PubMed PMID: 21530622; PMCID: PMC3109099.
  • Song Y, Ambati J, Parkin S, Rankin SE, Robertson LW, Lehmler HJ. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere. 2011 Aug 6. [Epub ahead of print] PubMed PMID: 21824639.
  • Wagner BA, Venkataraman S, Buettner GR. The rate of oxygen utilization by cells. Free Radic Biol Med. 2011 Aug 1; 51 (3) :700-12. PubMed PMID:21664270; PubMed Central PMCID: PMC3147247 [Available on 2012/8/1].
  • Zhai G, Hu D, Lehmler HJ, Schnoor JL. Enantioselective biotransformation of chiral PCBs in whole poplar plants. Environ Sci Technol. 2011 Mar 15;45(6):2308-16. Epub 2011 Feb 17. PMID: 21329345; PMCID: PMC3066656 [Available on 2012/3/15]

2010

  • Aken BV, Correa PA, Schnoor JL. Phytoremediation of polychlorinated biphenyls: new trends and promises. Environ Sci Technol. 2010 Apr 15; 44 (8) :2767-76. PMCID: PMC3025541.
  • Chan, K., H.-J. Lehmler, M. Sivagnanam, C. Yan Feng, L. W. Robertson, P. J. O’Brien. Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes. J. Appl. Toxicol. 2010 Mar;30(2):163-71. PMID: 19830680.
  • Correa P.A.; L. Lin; C.L. Just; D. Hu; K.C. Hornbuckle; J.L .Schnoor; B. Van Aken. The Effects of Individual PCB Congeners on the Soil Bacterial Community Structure and the Abundance of Biphenyl Dioxygenase Genes. Environ Intl. 2010 Nov; 36(8):901-6. epub 2009 Aug 28.. PMID: 19716603.
  • Duffel, M.W. Sulfotransferases. In: Biotransformation: Volume 4 of Comprehensive Toxicology (F.P. Guengerich, ed.). Elsevier, Oxford, (accepted March, 2008). In Press. 2010.
  • Flor S, Ludewig G. Polyploidy-induction by dihydroxylated monochlorobiphenyls: structure-activity-relationships. Environ Int. 2010 Nov; 36 (8) :962-9. PMCID: PMC2949501.
  • Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G. 3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ Int. 2010 Nov; 36 (8) :970-9. PMCID: PMC2949545.
  • Kania-Korwel, I., M.H.M.E. El-Komy, P. Veng-Pedersen, H.-J. Lehmler (2010). Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57Bl/6 mice. Environ. Sci. Technol. 2010 Apr 15;44(8):2828-35. PMCID: PMC2855138.
  • Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int. 2010 Nov; 36 (8) :918-23. PMCID: PMC2891598.
  • Lehmler, H-J, S. J. Harrad, H. Hühnerfuss, I. Kania-Korwel, C. M. Lee, Z. Lu, C. S. Wong (2010). Chiral polychlorinated biphenyl transport, metabolism and distribution – A review. Environ. Sci. Technol. 2010 Apr 15;44(8):2757-66. PMCID: PMC2855137
  • Lehmler HJ, Telu S, Vyas SM, Shaikh NS, Rankin SE, Knutson BL, Parkin S. Synthesis and Solid State Structure of Fluorous Probe Molecules for Fluorous Separation Applications. Tetrahedron. 2010 Apr 3; 66 (14) :2561-2569. PMCID: PMC2840617.
  • Li X., S. Parkin, M.W. Duffel, L.W. Robertson and H.-J Lehmler. 3',4'-Dichlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. (2010). E66, o1615–o1616. Open Access PDF
  • Li, X., S. Parkin, M. W. Duffel, L. W. Robertson, H.-J. Lehmler (2009). An efficient approach to sulfate metabolites of polychlorinated biphenyls. Environ. Intl. 2010 Nov;36(8):843-8. Epub 2009 Apr 5. PMID: 19345419.
  • Li X., S. Parkin, M.W. Duffel, L.W. Robertson, H.-J. Lehmler, Biphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. E 2010: 66, o1073. Open Access PDF
  • Martinez A. , K. Norström, K. Wang, K.C. Hornbuckle. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan. Environ. Intl, 2010 Nov;36(8):849-54. Epub 2009 Mar 5. PMCID: PMC2888873.
  • Milanowski B, Lulek J, Lehmler HJ, Kania-Korwel I. Assessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses. Environ Int. 2010 Nov; 36 (8) :884-92. PMCID: PMC2891895.
  • Norström K.; G. Czub; M.S. McLachlan; D. Hu; P.S. Thorne; K.C. Hornbuckle. External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment. Environ Intl, 2010 Nov;36(8):855-61. Epub 2009 Apr 24. PMCID: PMC2891214
  • Persoon, C., T. M. Peters, K. Kumar, K. C. Hornbuckle. Spatial distribution of airborne polychlorinated biphenyls in Cleveland, Ohio and Chicago, Illinois. Environ. Sci. Technol., 2010 Apr 15;44(8):2797-802. PMCID: PMC2855146.
  • Song Y, Buettner GR. Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide. Free Radic Biol Med. 2010 Sep 15; 49 (6) :919-62. PMCID: PMC2936108.
  • Song Y., S. Parkin, H.-J. Lehmler. 1-Bromo-2,3,6-trichloro-4,5-dimethoxy-benzene. Acta Cryst. E 2010: E66, o487. Open Access PDF
  • Song Y., S. Parkin, H.-J. Lehmler, 1-Bromo-4-chloro-2,5-dimethoxybenzene. Acta Cryst. E 2010: E66, o339. Open Access PDF
  • Telu S, Parkin S, Robertson LW, Lehmler HJ. Improved syntheses of non-dioxin-like polychlorinated biphenyls (PCBs) and some of their sulfur-containing metabolites. Environ Int. 2010 Nov; 36 (8) :828-34. PMCID: PMC2948577.
  • Xie W, Bothun GD, Lehmler HJ. Partitioning of perfluorooctanoate into phosphatidylcholine bilayers is chain length-independent. Chem Phys Lipids. 2010 Mar; 163 (3) :300-8. PMCID: PMC2841784.
  • Xie W, Ludewig G, Wang K, Lehmler HJ. Model and cell membrane partitioning of perfluorooctanesulfonate is independent of the lipid chain length. Colloids Surf B Biointerfaces. 2010 Mar 1; 76 (1) :128-36. PMCID: PMC2818369.
  • Xie W, Wang K, Robertson LW, Ludewig G. Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites. Environ Int. 2010 Nov; 36 (8) :950-61. PMCID: PMC2888624.
  • Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Identification of hydroxylated metabolites of 3,3′,4,4′-tetrachlorobiphenyl and metabolic pathway in whole poplar plants, Chemosphere 81, 523-528, DOI: 10.1016/j.chemosphere.2010.07.036, PMID: 20708213, PMCID:PMC2943055.
  • Zhai, GS; Lehmler, HJ; Schnoor, JL (2010). Hydroxylated Metabolites of 4-Monochlorobiphenyl and Its Metabolic Pathway in Whole Poplar Plants, Environ. Sci. Technol. 44, 3901-3907, DOI: 10.1021/es100230m, PMID: 20402517, PMCID: PMC2891041.
  • Zhao H., A. Adamcakova-Dodd, D. Hu, K.C. Hornbuckle, C.L. Just, L.W. Robertson, P.S. Thorne, H.-J. Lehmler. Development of a Synthetic PCB Mixture Resembling the Average Polychlorinated Biphenyl Profile in Chicago Air. Environ Intl 2010 Nov;36(8):819-27. PMCID: PMC2888912.

2009

  • Dreiem A., S. Rykken, H.-J. Lehmler, L. W. Robertson, F. Fonnum. Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells. Toxicol. Appl. Pharmacol. 2009 Oct 15;240(2):306-13. PMCID: PMC2753730
  • Kloesener J, T. Peters, A. Dodd, L. Teesch, P.S. Thorne, L.W. Robertson, G. Luthe. Innovative application of fluoro-tagging to trace airborne particulate and gas phase PBDE exposures. Chem. Res. Toxicol. 2009 Jan;22(1):179-86. PMID: 19111055
  • Li, X., L. W. Robertson, H.-J. Lehmler. Electron ionization mass spectral fragmentation study of sulfation derivatives of polychlorinated biphenyls. Chem. Cent. J. 3: 5. 2009. PMCID: PMC2660904
  • Liu Y., J. Smart, Y. Song, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. 2009. Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status. Drug Metabol. and Disposi, 2009 May; 37(5): 1065–1072. Epub 2009 Feb 5. PMCID: PMC2677757
  • Persoon C., K. C. Hornbuckle. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere 2009. 74(7), 917-923. PMCID: PMC2657292
  • Pessah I.N., H.-J. Lehmler, L.W. Robertson, C.F. Perez, E. Cabrales, D. Bose, W. Feng. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem. Res. Toxicol. 2009 Jan;22(1):201-7. PMCID: PMC2662366
  • Ptak, A., G. Ludewig, A. Rak, W. Nadolna, M. Bochenek, E. L. Gregoraszczuk. Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxlylated metabolites on cellular apoptosis. Environ Intl. 2009 Jul 13. [Epub ahead of print]. PMID: 19604582 PMCID: PMC2904404 [Available on 2011/11/1]
  • Song Y., B. A. Wagner, J. R. Witmer, H.-J. Lehmler, G. R. Buettner. Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc. Natl. Acad. Sci. USA. 2009; 106:9725–9730. PMCID: PMC2689812
  • Spencer, W. A., H. J. Lehmler, L. W. Robertson, R. C. Gupta. Oxidative DNA adducts following Cu2+-mediated activation of dihydroxy PCBs: Role of reactive oxygen species. Free Radic. Biol. Med. 2009; 46(10): 1346-1352. PMCID: PMC2744390
  • Suh Y.-W., G. R. Buettner, S. Venkataraman, S. E. Treimer, L. W. Robertson, G. Ludewig. UVA/B-induced formation of free radicals from 2-decabromodiphenyl ether (deca-BDE). Environ. Sci. Technol. 2009; 43(7):2581-2588. PMCID: PMC2685467
  • Wangpradit O., S. Mariappan, L. Teesch, K. Norstrom, M. Duffel, L.W. Robertson, G. Luthe. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem. Res. Toxicol. 2009 Jan: 22(1):64-71. PMCID: PMC2637223
  • Wombacher W.D. and K.C. Hornbuckle. Synthetic Musk Fragrances in a Conventional Drinking Water Treatment Plant with Lime Softening.SCE J Environ. Engin. 2009, 135(11): 1192-1198. http://dx.doi.org/10.1061/(ASCE)EE.1943-7870.0000085.
  • Xie, W., Q. Wu, I. Kania-Korwel, J. C. Tharappel, S. Telu, M. C. Coleman, H.P. Glauert, K. Kannan, S.V. Santhana Mariappan, D.R. Spitz, J. Weydert, H.-J. Lehmler. Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats. Arch. Toxicol 2009 Oct;83(10):909-24. PMCID: PMC2755535

2008

  • Glauert H.P., J.C. Tharappel, S. Banerjee, N. L.S. Chan, I. Kania-Korwel, H.-J. Lehmler, E.Y. Lee, L.W. Robertson, B.T. Spear. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappaB in mice. Toxicol. Appl. Pharmacol. 232, 302-308 (2008). PMCID: PMC2583134
  • Glauert H.P., J.C. Tharappel, Z. Lu, D. Stemm, S. Banerjee, L.S. Chan, E.Y. Lee, H.-J. Lehmler, L.W. Robertson and B.T. Spear, Role of oxidative stress in the promoting activities of PCBs. Environ. Toxicol. Pharmacol. 25, 247-250 (2008). PMID: 19122744.
  • Gregoraszczuk E.L., A. Rak, G. Ludewig and A. Gasin´ska. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environ. Toxicol. Pharmacol. 2008; 25(2): 227-233. Abstract
  • Gulcan H.O., L. Yungang and M.W. Duffel. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chemical Research in Toxicology, 21:1503-8. PMCID: PMC2548291
  • Hu, D.; Martinez, A.; Hornbuckle, K.C. Discovery of non-aroclor PCB (3,3′-Dichlorobiphenyl) in Chicago air. Environ. Sci. Technol.; 2008; 42(21); 7873-7877. PMCID: PMC2646757
  • Jacobus J.A., S. Flor, A.J. Klingelhutz, L.W. Robertson and G. Ludewig, 2-(4-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres. Environ. Toxicol. Pharmacol. 2008; 25, 267-272. PMCID: PMC2346440
  • Kania-Korwel I., K.C. Hornbuckle, L.W. Robertson, and H.-J. Lehmler. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food and Chemical Toxicology 46, 637–644 (2008). PMCID: PMC2289907
  • Kania-Korwel I., K. Hornbuckle, L. Robertson, H.-J. Lehmler. Dose-Dependent Enantiomeric Enrichment of 2,2',3,3',6,6'-Hexachlorobiphenyl in Female Mice. Environ Toxicol Chem. 27, 299-305 (2008). PMID: 18348647
  • Kania-Korwel I., S.M. Vyas, Y. Song, H.-J. Lehmler. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J. Chromatogr. A 2008:1207, 146-154. PMCID: PMC2579784
  • Kania-Korwel I., W. Xie, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantiomeric enrichment of 2,2’,3,3’,6,6’-hexachlorobiphenyl (PCB 136) in mice after induction of CYP enzymes. Arch. Environ. Contam. Toxicol. 2008: 55, 510-517. PMID: 18437444
  • Kania-Korwel I , E.G. Hrycay, S.M. Bandiera, H.-J. Lehmler. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem. Res. Toxicol. Vol 21 (6), 1295-1303, 2008. PMCID: PMC2574739
  • Kania-Korwel I., H. Zhao, K. Norstrom, X. Li, K.C. Hornbuckle, H.-J. Lehmler, Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J. Chromatogr. A 2008 Dec 19;1214(1-2):37-46. Epub 2008 Oct 31. PMCID: PMC2648864
  • Klösener J., D. C. Swenson, L. W. Robertson and G. Luthe. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Cryst. B64, 108–119 (2008). PMID: 18204217
  • Lehmler H.J., L. Xu, S.M. Vyas, V.A. Ojogun B.L. Knutson and G. Ludewig. Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle. Journal of Pharmaceutics, Vol 353 (1-2), 35-44, 2008. PMCID: PMC2408535
  • Li X., S. Parkin, L. W. Robertson, H.-J. Lehmler. 4’-Chlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. E64, o2464 (2008). Open Access PDF
  • Liu J., J. L. Schnoor. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere, 73(10), November 2008: 1608-1616. PMCID: PMC2668963
  • Ludewig G., L. Lehmann, H. Esch and L.W. Robertson. Metabolic activation of PCBs to carcinogens in vivo—A review. Environ. Toxicol. Pharmacol. 2008; 25, 241-246. PMCID: PMC2364599
  • Luthe G., R. Boy, J. Jacobus, B. Smith, A. Rahaman, L. W. Robertson, G. Ludewig. Xenobiotic Geometry and Media pH determine Cytotoxicity through Solubility. Chem. Res. Toxicol. Vol 21 (5), 1017-1027, 2008. PMID: 18402468
  • Luthe G., J.A. Jacobus and L.W. Robertson. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment. Environ. Toxicol. Pharmacol. 2008; 25, 202-210. PMCID: PMC2746664
  • Maddox C., B. Wang, P.A. Kirby, K. Wang, and G. Ludewig. Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats. Environ. Toxicol. Pharmacol. 2008; 25(2), 260-266. PMCID: PMC2346436
  • Persoon C., K.C. Hornbuckle. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere. 2009 Feb;74(7):917-23. Epub 2008 Dec 9. PMCID: PMC2657292
  • Ptak, A., G. Ludewig, E. L. Gregoraszczuk. A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J. Physiol. Pharmacol. 2008: 59(3), 577-588. PMID: 18953099
  • Ravoori S., P. Ayotte, C. Srinivasan, D. Pereg, L.W. Robertson, G.K. Russell, J. Jeyabalan and R.C. Gupta. DNA damage associated with PCBs in the whole blood cells of Inuit. Environmental Toxicology and Pharmacology 25, 273-276 (2008). Abstract
  • Robertson L.W., W. Sulkowski and B. Hennig, Preface. Special Issue of ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, FOCUS ON PCBs: RECENT ADVANCES IN ENVIRONMENTAL DISTRIBUTION AND HEALTH EFFECTS, Guest Editors: Larry Robertson, Wieslaw Sulkowski and Bernhard Hennig, Vol. 25, issue 2 March 2008, 127.
  • Sacco J.C., H.-J. Lehmler, L.W. Robertson, W. Li, and M.O. James. Glucuronidation of polychlorinated biphenylols and UDPGA concentration in channel catfish liver and intestine. Drug Metabolism and Disposition 36, 623–630 (2008). PMID: 18180271
  • Shaikh N.S. , S. Parkin, G. Luthe, H.-J. Lehmler. The three-dimensional structure of 3,3′,4,4′-tetrachlorobiphenyl, a dioxin-like polychlorinated biphenyl (PCB), Chemosphere. 2008 February; 70(9): 1694–1698. PMCID: PMC2430941
  • Song Y., G. Buettner, S. Parkin, B. Wagner, L.W. Robertson, H.-J. Lehmler. Chlorination Increases the Persistence of Semiquinone Free Radicals Derived from Polychlorinated Biphenyl Hydroquinones and Quinones. Journal of Organic Chemistry 73, 8296-8304 (2008). PMCID: PMC2629131
  • Song Y., B.A. Wagner, H.-J. Lehmler, G.R. Buettner. Semiquinone radicals from oxygenated polychlorinated biphenyls: Electron paramagnetic resonance studies. Chem. Res. Toxicol. 2008; 21(7), 1359-1367. PMCID: PMC2740386
  • Stemm D.N., J.C. Tharappel, H.-J Lehmler, C. Srinivasan, J. S. Morris, V.L. Spate, L.W. Robertson, B.T. Spear and H.P. Glauert. Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3’,4,4’-Tetrachlorobiphenyl and 2,2’,4,4’,5,5’-Hexachlorobiphenyl. Exp. Biol. Med. 233, 366–376 (2008). PMID: 18296742
  • Telu S., S. Parkin, L.W. Robertson, H.-J. Lehmler, 1,3,5-Trichloro-2-methoxybenzene. Acta Cryst. E 2008: 64, o424. Full-text PDF
  • Tharappel J.C., H.-J. Lehmler, C. Srinivasan, L.W. Robertson, B.T. Spear, H.P. Glauert. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3’,4,4’-tetrachlorobiphenyl (PCB-77). Food Chem. Toxicol. 2008; 46, 3467-3474. PMCID: PMC2597727
  • Venkatesha V.A., S. Venkataraman, E.H. Sarsour, A.L. Kalen, G.R. Buettner, L.W. Robertson, H.-J. Lehmler, P.C. Goswami. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in non-malignant human breast epithelial cells. Free Radic. Biol. Med. 2008: 45, 1094-1102. PMCID: PMC2614346

2007

  • Bunaciu R.P., J.C. Tharappel, H.-J. Lehmler, I. Korwel, L.W. Robertson, C. Srinivasan, B.T. Spear, and H.P. Glauert. The Effect of Dietary Glycine on the Hepatic Tumor Promoting Activity of Polychlorinated Biphenyls (PCBs) in Rats. Toxicology 239, 147–155 (2007). PMCID: PMC2063585
  • Kania-Korwel I., N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-Hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 2007: 19, 56-66. PMID: 17089340
  • Lehmann L., H.L. Esch, P.A. Kirby, L.W. Robertson, G. Ludewig. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478, 2007. PMID: 16950798
  • Ludewig G., H. Esch, L.W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094, 2007.
  • Luthe G., D. C. Swenson and L.W. Robertson. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3), Acta Crystallographica, Section B: Structural Science 63, 319-327 (2007). PMID: 17374943
  • Robertson L. W., I. Berberian, T. Borges, L. Chen, C.K. Chow, H.P. Glauert, J.G. Filser and H. Thomas. Suppression of peroxisomal enzyme activities and cytochrome P-4504A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR Research, vol. 2007, Article ID 15481, 5 pages, 2007. PMCID: PMC2220027
  • Sadeghi-aliabadi H., K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem.-Biol. Interactions 2007: 167, 184-192. PMID: 17408604
  • Song Y., S. Parkin, H.-J. Lehmler. 4-Bromo-2-chloro-1-methoxybenzene. Acta Cryst. E 2007: 63, o2091-o2092.
  • Strathmann, J., K. Paal, C. Ittrich, E. Krause, K. E. Appel, H. P. Glauert, A. Buchmann, M. Schwarz. Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics 2007; 7(18): 3318-3331. PMID: 17722141.
  • Zettner M.A., S. Flor, G. Ludewig, J. Wagner, L.W. Robertson, L. Lehmann. Quinoid Metabolites of 4-monochlorobiphenyl (PCB3) Induce Gene Mutations in Cultured Chinese Hamster V79 Cells. Toxicological Sciences 100, 88–98 (2007). PMID: 17686921

2006

  • Bender R.P., H.-J. Lehmler, L.W. Robertson, G. Ludewig, N. Osheroff. Polychlorinated Biphenyl Quinone Metabolites Poison Human Topoisomerase IIalpha: Altering Enzyme Function by Blocking the N-Terminal Protein Gate. Biochemistry. PMID: 16906772
  • Gooding, M.P., T.J. Newton, M.R. Bartsch, K.C. Hornbuckle. Toxicity of synthetic musks to early life stages of the freshwater mussel Lampsilis cardium. Arch. Environ. Contam. Toxicol. 51(4): 549-558 (2006). PMID: 16944041. PMCID: PMC2757453
  • Hornbuckle, K. C., D. L. Carlson, D. L. Swackhamer, J. E. Baker, S. J. Eisenreich. Polychlorinated Biphenyls in the Great Lakes. In The Handbook in Environmental Chemistry/Water Pollution. R. A. Hites. Heidelberg, Springer-Verlag: 13-70 (2006).
  • Kania-Korwel I., A.W. Garrison, J.K. Avants, K.C. Hornbuckle, L.W. Robertson, W.W. Sulkowski, H.-J. Lehmler, Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat. Environmental Science & Technology 40, 3704-3710 (2006). Open Access PDF
  • Kunz S., H.-J. Schmitz, A. Buchmann, M. Schwarz, B. Schilling, O. Päpke, H.-J. Lehmler, L.W. Robertson and D. Schrenk. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicology Letters 164, 133–143 (2006). PMID: 16426774
  • Liu Y., T.I. Apak, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem. Res. Toxicol. 2006: 19, 1420-1425. PMID: 17112228
  • Luthe G., P.E.G. Leonards, G.S. Reijerink, H. Liu, J.E. Johansen, L.W. Robertson, Monofluorinated analogues of polybrominated diphenyl ethers (F-PBDEs) as analytical standards: Synthesis, NMR and GC-MS characterization and molecular orbital studies. Environ Sci Technol 2006: 40, 3023-3029. PMID: 16719106
  • Peck, A.M., K.C. Hornbuckle. Environmental sources, occurrence, and effects of synthetic musk fragrances. J. Environ. Monit. 2006: 8(9), 874-879.
  • Peck, A. M., K. C. Hornbuckle. Synthetic musk fragrances in urban and rural air of North America. Atmos. Environ. 2006: 40(32), 6101-6111.
  • Peck, A. M., E. Linebaugh, K. C. Hornbuckle. Synthetic musk fragrances in Lake Erie and Lake Ontario sediment cores. Environ. Sci. Technol. 2006: 40(16), 5629-5635. PMCID: PMC2757450
  • Ptak A., G. Ludewig, M. Kapiszewska, Z. Magnowska, H.J. Lehmler, L.W. Robertson, E.L. Gregoraszczuk. Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicology Letters 166, 200-211, 2006. PMID: 16949219
  • Ptak A., G. Ludewig, L.W. Robertson, H.-J. Lehmler and E.L. Gregoraszczuk. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters 164, 113–122 (2006). PMID: 16412591
  • Shaikh, N. S., S. Parkin, H.-J. Lehmler. 2,2',3,3',6,6'-Hexachloro-5-nitro-1,1'-biphenyl (5-Nitro PCB 136). Acta Cryst. E 2006: E62(2), o662-o663.
  • Shaikh N.S., D.C. Swenson, H.-J. Lehmler. 2,3,6-Trichloroiodobenzene. Acta Cryst. E 2006: 62, o4672-o4673.
  • Strathmann J., M. Schwarz, J.C. Tharappel, H. P. Glauert, B.T. Spear, L.W. Robertson, K.E. Appel, A. Buchmann. PCB 153, a non-dioxin-like tumor promoter, selects for ß-Catenin (Catnb) mutated mouse liver tumors. Toxicol. Sci. PMID: 16782779
  • Vyas, S. M., S. Parkin, H.-J. Lehmler. 2,2',3,4,4',5,5'-Heptachlorobiphenyl (PCB 180). Acta Cryst. E 2006; E62(7): o2905-o2906.
  • Vyas S.M., S. Parkin, L.W. Robertson, H.-J. Lehmler. 2,5-Dichloro-4'-methoxybiphenyl. Acta Cryst. E 2006: 62, o4162–o4163. Full-text PDF (with permission from publisher)
  • Vyas S.M., S. Parkin, L.W. Robertson, H-J. Lehmler. 4 -Chloro-2’,3’-dimethoxybiphenyl. Acta Crystallographica Section E E62, o3639–o3640 (2006). Full-text PDF (with permission from publisher)
  • Wang L.-Q., H.-J. Lehmler, L.W. Robertson, and M.O. James. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem.-Biol. Interactions 159, 235-246 (2006). PMID: 16413005
  • Weldon, M B., K.C. Hornbuckle. Concentrated animal feeding operations, row crops and their relationship to nitrate in Eastern Iowa rivers. Environ. Sci. Technol. 2006; 40(10): 3168-3173. PMCID: PMC2745718.